1429651-50-2
1429651-50-2 structure
- Name: HPOB
- Chemical Name: hpob
- CAS Number: 1429651-50-2
- Molecular Formula: C17H18N2O4
- Molecular Weight: 314.336
- Catalog: Biochemical Inhibitor Epigenetics HDAC inhibitor
- Create Date: 2016-04-19 19:03:08
- Modify Date: 2024-01-14 11:57:40
-
HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.target: HDAC6 [1]IC 50: 56nM [1]In vitro: HPOB causes growth inhibition of normal and transformed cells but does not induce cell death. HPOB enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells. [1] Neuroprotective effect of HPOB demonstrated the crucial role of HDAC6 inhibition in reducing Cort-induced apoptosis in PC12 cells. Pre-treatment with HPOB remarkably reduces Cort-induced cytotoxicity and confirms the anti-apoptotic effect of HPOB via the caspase-3 activity assay and H33342/PI and TUNEL double staining. [2]In vivo: on corticosterone (Cort)-induced apoptosis and explors the possible mechanism of action of HPOB in rat adrenal pheochromocytoma (PC12) cells, which possesses typical neuron features and expresses high levels of glucocorticoid receptors. [2]
| Name | hpob |
|---|---|
| Synonyms |
N-Hydroxy-4-{2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl}benzamide
4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl- |
| Description | HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.target: HDAC6 [1]IC 50: 56nM [1]In vitro: HPOB causes growth inhibition of normal and transformed cells but does not induce cell death. HPOB enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells. [1] Neuroprotective effect of HPOB demonstrated the crucial role of HDAC6 inhibition in reducing Cort-induced apoptosis in PC12 cells. Pre-treatment with HPOB remarkably reduces Cort-induced cytotoxicity and confirms the anti-apoptotic effect of HPOB via the caspase-3 activity assay and H33342/PI and TUNEL double staining. [2]In vivo: on corticosterone (Cort)-induced apoptosis and explors the possible mechanism of action of HPOB in rat adrenal pheochromocytoma (PC12) cells, which possesses typical neuron features and expresses high levels of glucocorticoid receptors. [2] |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.056 μM (IC50) HDAC3/NCOR2:1.7 μM (IC50) HDAC8:2.8 μM (IC50) HDAC1:2.9 μM (IC50) HDAC10:3.0 μM (IC50) HDAC2:4.4 μM (IC50) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H18N2O4 |
| Molecular Weight | 314.336 |
| Exact Mass | 314.126648 |
| PSA | 89.87000 |
| LogP | -0.05 |
| Appearance | white to beige |
| Index of Refraction | 1.649 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
| RIDADR | NONH for all modes of transport |
|---|