74466-66-3

74466-66-3 structure

Name: 1,3'-Dimethylguanosine
Chemical Name: 1,3'-Dimethylguanosine
CAS Number: 74466-66-3
Molecular Formula: C₁₂H₁₇N₅O₅
Molecular Weight: 311.29
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2016-04-27 19:15:48
Modify Date: 2026-09-17 18:30:21
1,3'-Dimethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1,3'-Dimethylguanosine
Synonyms	2-amino-9-(3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-1-methyl-1,9-dihydro-6H-purin-6-one 1,2'-O-Dimethyl guanosine 1,2’-O-Dimethylguanosine N1-Methyl-3’-O-methyl guanosine Guanosine, 1-methyl-3'-O-methyl- (9CI)

Description	1,3'-Dimethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. [2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.