Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Piperonyl butoxide
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: piperonyl butoxide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

51-03-6

51-03-6 structure

Name: Piperonyl butoxide
Chemical Name: piperonyl butoxide
CAS Number: 51-03-6
Molecular Formula: C₁₉H₃₀O₅
Molecular Weight: 338.439
Catalog: Chemical pesticide Insecticide Fumigant
Create Date: 2018-06-22 16:35:08
Modify Date: 2026-06-29 16:37:24
Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.

Name	piperonyl butoxide
Synonyms	INCITE Piperonylbutoxide 5-[2-(2-BUTOXYETHOXY)ETHOXYMETHYL]-6-PROPYL-1,3-BENZODIOXOLE 3,4-METHYLENE-DIOXY-6-PROPYLBENZYL-N-BUTYL DIETHYLENE GLYCOL ETHER Vex Butacid 2-(2-Butoxyethoxy)ethyl (6-propylpiperonyl) ether, 4,5-Methylenedioxy-2-propylbenzyldiethyleneglycol butyl ether Butocide PIPERONYL BUTOXIDE 3-Benzodioxole,5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-1 butoxide(synergist) PBO Diperonyl butoxide 6-(Propylpiperonyl)-butyl cbityl ether Piperonylbutoxide ade PIPERONALBUTOXIDE alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene BUTOXIDE(R) 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-3-benzodioxole alpha-(2-(2-n-butoxyethoxy)-ethoxy-4,5-methylenedioxy-2-propyltoluene α-[2-(2-Butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene 5-{[2-(2-butoxyethoxy)ethoxy]Methyl}-6-propyl-2H-1,3-benzodioxole (BUTYLCBITYL)(6-PROPYL-PIPERONYL) ETHER (3,4-METHYLENEDIOXY-6-PROPYLBENZYL)(BUTYL) DIETHYLENE GLYCOL ETHER EINECS 200-076-7 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxole 2-(2-Butoxyethoxy)ethyl (6-propylpiperonyl) ether 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether 1-(benzo[d][1,3]dioxol-5-yl)pentan-2-olate nia5273 Butacide 6-PROPYLPIPERONYL BUTYL DIETHYLENE GLYCOL ETHER pieronyl butoxide 2-(2-Butoxyethoxy)ethyl (6-propylpiperonyl) ether 4,5-Methylenedioxy-2-propylbenzyldiethyleneglycol butyl ether 5-[2-(2-Butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole PBO 6-Propylpiperonyl butyl diethylene glycol ether 5-[[2-(2-Butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene 1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl 'L' 5-{[2-(2-Butoxyethoxy)ethoxy]methyl}-6-propyl-1,3-benzodioxole 3,4-methylenedioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyl-toluen Piperronyl butoxide 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether (3,4-methylenedioxy-6-propylbenzyl)(butyl)diethyleneglicolether Poperonyl butoxide a-[2-(2-Butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene BUTACIDE(R) Pyrenon 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole PIPERONYL BUTOXIDE, 100MG,NEAT Piperonylbutoxide,2-(2-Butoxyethoxy)ethyl (6-propylpiperonyl) ether, 4,5-Methylenedioxy-2-propylbenzyldiethyleneglycol butyl ether piperonyl butoxide (ban,bsi,iso,esa) FAC-S273 butocide 5-{[(2-{[2-(butyloxy)ethyl]oxy}ethyl)oxy]methyl}-6-propyl-1,3-benzodioxole A-[2-(2-BUTOXYETHOXY)ETHOXY]-4,5-METHYLENEDIOXY-2-PROPYLTOLUENE 4,5-METHYLENEDIOXY-2-PROPYLBENZYLDIETHYLENEGLYCOL BUTYL ETHER Butylcarbityl (6-propylpiperonyl) ether PRENTOX SANEX FLY KILLER 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propylbenzo[d][1,3]dioxole 5-propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol Piperonyl butoxide Solution, 1000ppm 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-3-benzodioxole 2-(2-BUTOXYETHOXY)ETHYL (6-PROPYLPIPERONYL) ETHER [3,4-(Methylenedioxy)-6-propylbenzyl] Butyl Diethyleneglycol Ether Butoxide PIPERONYL BUTOXIDE PESTANAL BUTACIDE piperonyl-butoxide Alleviate fmc5273 MFCD00005842 5-{[2-(2-butoxyethoxy)ethoxy]methyl}-6-propyl-2H-1,3-benzodioxole alpha(2-(2-Butoxyethoxy)ethoxy)-4,5-methylenedioxy-2-propyltoluene

Description	Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection

Density	1.1±0.1 g/cm3
Boiling Point	396.2±0.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₀O₅
Molecular Weight	338.439
Flash Point	165.3±27.2 °C
Exact Mass	338.209320
PSA	46.15000
LogP	4.23
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.503
Stability	Stable. Combustible. Incompatible with oxidizing agents.
Water Solubility	<0.1 g/100 mL at 18 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS8050000

CHEMICAL NAME :: Toluene, alpha-(2-(2-butoxyethoxy)ethoxy)-4,5-(methylenedioxy) -2-propyl-

CAS REGISTRY NUMBER :: 51-03-6

BEILSTEIN REFERENCE NO. :: 0288063

LAST UPDATED :: 199806

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C19-H30-O5

MOLECULAR WEIGHT :: 338.49

WISWESSER LINE NOTATION :: T56 BO DO CHJ G3 H1O2O2O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Skin and Appendages - hair

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3850 mg/kg/7D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 109 gm/kg/13W-C

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 gm/kg/6W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mL/kg/31D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 548 gm/kg/2Y-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19936 mg/kg/7W-C

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg/7D-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 mg/kg/6W-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 109 mL/kg/1Y-I

TOXIC EFFECTS :: Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 526 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 263 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 262 gm/kg/1Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2130 mg/kg

SEX/DURATION :: female 11-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3600 mg/kg

SEX/DURATION :: female 11-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 gm/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1065 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1385 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 89600 ug/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 9 gm/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 9 gm/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,249,1996 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,183,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,183,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 7,243,1974 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80218 No. of Facilities: 5179 (estimated) No. of Industries: 46 No. of Occupations: 34 No. of Employees: 58709 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80218 No. of Facilities: 5234 (estimated) No. of Industries: 43 No. of Occupations: 37 No. of Employees: 89064 (estimated) No. of Female Employees: 20721 (estimated)

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	T:Toxic
Risk Phrases	R24;R51/53
Safety Phrases	S60-S61-S45-S36/37/39-S28A
RIDADR	UN 3082 9/PG 3
WGK Germany	3
RTECS	XS8050000
Packaging Group	III
Hazard Class	6.1(b)

1938-32-5

112-34-5

~74%

51-03-6

Literature: Wang, Shuai; Liu, Jinqiang; Qian, Chao; Chen, Xinzhi Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 147 - 160

1938-32-5

51-03-6

Literature: Schmidt; Dahm J. econ. Entomol., 1956 , vol. 49, p. 729,730

94-58-6

51-03-6

Literature: U.S. Ind. Chem. Inc. Patent: US2485680 , 1946 ;

Precursor 3
1938-32-5 112-34-5 94-58-6
DownStream 1
1938-32-5

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