13220-57-0

13220-57-0 structure

Name: Tryptanthrine
Chemical Name: Couroupitine A Indolo(2,1-b)quinazoline-6,12-dione Tryptanthrine
CAS Number: 13220-57-0
Molecular Formula: C₁₅H₈N₂O₂
Molecular Weight: 248.23600
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-04 08:48:10
Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC50 = 10 µM) and reduces LTB4 levels in the rat pleurisy model[1].

Name	Couroupitine A Indolo(2,1-b)quinazoline-6,12-dione Tryptanthrine
Synonyms	Tryptanthrin MFCD00012073 indolo[2,1-b]quinazoline-6,12-dione

Description	Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC50 = 10 µM) and reduces LTB4 levels in the rat pleurisy model[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 10 µM (LT formation in human whole blood)[1]
References	[1]. Pergola C, et al. On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.Br J Pharmacol. 2012 Feb;165(3):765-76.

RIDADR	NONH for all modes of transport
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%