891025-25-5

891025-25-5 structure

Name: BAMB-4
Chemical Name: Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl
CAS Number: 891025-25-5
Molecular Formula: C₁₅H₁₂N₂O₂
Molecular Weight: 252.26800
Catalog: Research Areas Cancer
Create Date: 2017-03-04 21:40:14
Modify Date: 2024-01-02 19:24:08
BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.IC50 value: 37 uMTarget: ITPKA inhibitorBAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy.

Name	Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl
Synonyms	BAMB-4

Description	BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.IC50 value: 37 uMTarget: ITPKA inhibitorBAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.