BAMB-4
Modify Date: 2024-01-02 19:24:08
BAMB-4 structure
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Common Name | BAMB-4 | ||
|---|---|---|---|---|
| CAS Number | 891025-25-5 | Molecular Weight | 252.26800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAMB-4BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.IC50 value: 37 uMTarget: ITPKA inhibitorBAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy. |
| Name | Benzamide, N-1,2-benzisoxazol-3-yl-4-methyl |
|---|---|
| Synonym | More Synonyms |
| Description | BAMB-4(ITPKA-IN-C14) is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA) with IC50 of 37 uM in ADP-Glo Assay.IC50 value: 37 uMTarget: ITPKA inhibitorBAMB-4 exhibit the lowest inhibition frequency among the InsP3-Kinase inhibitors. only in one from 42 targets tested,BAMB-4 showed an inhibitory effect. Noteworthy, in kinasescreens no targets of BAMB-4 were detected, indicating that thecompound does not belong to the typical kinase inhibitors. Thus,the relative high speci?city and the high cellular uptake ofBAMB-4 now for the ?rst provide the possibility to effectively inhibit InsP3kinase in vivo. e InsP3Kinase activity is essentially involved in ITPKA promoted metastasis of lung cancer cells, BAMB-4 is a promising therapeutic approach in lung cancertherapy. |
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| Related Catalog | |
| References |
| Molecular Formula | C15H12N2O2 |
|---|---|
| Molecular Weight | 252.26800 |
| Exact Mass | 252.09000 |
| PSA | 55.13000 |
| LogP | 3.46150 |
| Storage condition | 2-8℃ |
| BAMB-4 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: BAMB-4
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: BAMB-4(ITPKA-IN-C14)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: BAMB-4(ITPKA-IN-C14)
- Price: $500.0/100mg $900.0/250mg $1800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: $462/10mM*1mLinDMSO
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