487-60-5

487-60-5 structure

Name: Indican
Chemical Name: indican
CAS Number: 487-60-5
Molecular Formula: C₁₄H₁₇NO₆
Molecular Weight: 295.288
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-12-07 13:08:46
Modify Date: 2024-01-02 14:32:19
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

Name	indican
Synonyms	Indikan Plant indican Indican Indole, 3- (β-D-glucopyranosyloxy)- 3-Indolyl-b-D-glucopyranoside 3-Indole-D-glucoside Hydrate Indoxyl-D-glucoside Hydrate Indoxyl β-D-glucoside 1H-Indol-3-yl β-D-glucopyranoside 1H-Indol-3-yl β-glucopyranoside Indoxyl-b-D-glucoside 3-Indolyl-D-glucoside Hydrate Indoxyl-β-D-glucoside Indican Hydrate Uroxanthin 3-Indoxyl-beta-D-glucopyranoside 3-Indoxyl-D-glucoside Hydrate 3-(b-Glucosido)indole 1H-Indol-3-yl-b-D-glucopyranoside MFCD00047169 Indole, 3-(β-D-glucopyranosyloxy)- 3-Indoxyl-β-D-glucopyranoside β-D-Glucopyranoside, 1H-indol-3-yl

Description	Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1]. Animal Model: Male Spraguee Dawley rats weighing 330-400 g[1] Dosage: 20, 40 mg/kg Administration: Orally Result: Increased the systemic exposure and multidrug resistance-associated protein (MRP) of Methotrexate (MTX; 5.0 mg/kg).
References	[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140. [2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.

Density	1.6±0.1 g/cm3
Boiling Point	606.7±55.0 °C at 760 mmHg
Melting Point	57-58ºC
Molecular Formula	C₁₄H₁₇NO₆
Molecular Weight	295.288
Flash Point	320.7±31.5 °C
Exact Mass	295.105591
PSA	115.17000
LogP	-0.75
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.715
Storage condition	−20°C
Water Solubility	H2O: 0.1 M at 20 °C, clear to slightly hazy, colorless to faint yellow-green

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

Precursor 0
DownStream 1
7497-97-4

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%