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108321-05-7

108321-05-7 structure
108321-05-7 structure
  • Name: Phosphoribosyl pyrophosphate pentasodium
  • Chemical Name: 5-PHOSPHO-α-D-RIBOSYL DIPHOSPHATE SODIUM SALT
  • CAS Number: 108321-05-7
  • Molecular Formula: C5H8Na5O14P3
  • Molecular Weight: 499.98
  • Catalog: Biochemical Carbohydrate Monosaccharide
  • Create Date: 2018-07-14 22:20:03
  • Modify Date: 2024-01-08 12:17:25
  • Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP[1].
Name 5-PHOSPHO-α-D-RIBOSYL DIPHOSPHATE SODIUM SALT
Synonyms 5-Phospho-a-d-ribosyl-diphosphate sodiuM salt
α-D-Ribofuranose, 1-O-[hydroxy(phosphonooxy)phosphinyl]-, 5-(dihydrogen phosphate), sodium salt (1:4)
5-PHOSPHO-D-RIBOSE 1-DIPHOSPHAT
P-RIB-PP
5-PHOSPHORYLRIBOSE 1-PYROPHOSPHATE SODIUM SALT
5-PHOSPHO-D-RIBOSE 1-DIPHOSPHATE SODIUM SALT
5-Phospho-D-ribose 1-diphosphate pentasodium salt
PRPP pentasodium salt
5-phosphorylribose 1-pyrophosphate*sodium
P-RIB-PP,PRPP SODIUM SALT
Description Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP[1].
Related Catalog
Target

Human Endogenous Metabolite
In Vitro Phosphoribosyl diphosphate (PRPP) pentasodium is an important intermediate in cellular metabolism. PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate + ATP → PRPP + AMP. PRPP is ubiquitously found in living organisms and is used in substitution reactions with the formation of glycosidic bonds. PRPP is utilized in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, the cofactors NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol, and certain aminoglycoside antibiotics[1]. Phosphoribosyl diphosphate (5-Phosphoribosyl-l-pyrophosphate) pentasodium, a substrate shared by adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, accumulates in human erythrocytes lacking hypoxanthine-guanine phosphoribosyltransferase. 5-Phosphoribosyl-l-pyrophosphate added to purified adenine phosphoribosyltransferase stabilizes it against heat inactivation[2].
References

[1]. Schneiter R, et al. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p. Microbiology (Reading). 2000;146 Pt 12:3269-3278.

[2]. Greene ML, et al. Substrate stabilization: genetically controlled reciprocal relationship of two human enzymes. Science. 1970;167(3919):887-889.

Molecular Formula C5H8Na5O14P3
Molecular Weight 499.98
Exact Mass 477.879608
PSA 270.49000
Storage condition −20°C
Water Solubility H2O: 50 mg/mL, clear, colorless to very faintly yellow
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H371
Precautionary Statements P260
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22-68/20/21/22
Safety Phrases 36/37
RIDADR NONH for all modes of transport
WGK Germany 3

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title: CAS No. 108321-05-7 | Chemsrc address: https://m.chemsrc.com/en/baike/670255.html

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