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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SPIZOFURONE
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Purity: 98.0%
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72492-12-7

72492-12-7 structure

72492-12-7 structure

Name: SPIZOFURONE
Chemical Name: spizofurone
CAS Number: 72492-12-7
Molecular Formula: C₁₂H₁₀O₃
Molecular Weight: 202.20600
Create Date: 2018-07-11 04:43:37
Modify Date: 2026-07-08 18:40:17

Name	spizofurone
Synonyms	Espizofurona [spanish] Ccris 1'-cyclopropane]-3-one 5-acetylspiro[benzo[b]furan-2(3H) 5-acetyl-3H-spiro[benzofuran-2,1'-cyclopropan]-3-one Espizofurona Maon Spiro(benzofuran-2(3H),1'-cyclopropan)-3-one, 5-acetyl 5-acetylspiro<benzofuran-2(3H),1'-cyclopropan>-3-one 5-Acetylspim[benzofuran-2(3H)-1’-cyclopropan]-3-one Spizofuronum 5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one AG-629 Brn 5-acetylspiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

Density	1.33 g/cm3
Boiling Point	396.3ºC at 760 mmHg
Melting Point	150-155ºC
Molecular Formula	C₁₂H₁₀O₃
Molecular Weight	202.20600
Flash Point	180.6ºC
Exact Mass	202.06300
PSA	43.37000
LogP	1.99690
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9807500

CHEMICAL NAME :: Spiro(benzofuran-2(3H),1'-cyclopropan)-3-one, 5-acetyl-

CAS REGISTRY NUMBER :: 72492-12-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H10-O3

MOLECULAR WEIGHT :: 202.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5440 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 609 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1610 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1740 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1770 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 gm/kg/5W-C

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,547,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/26W-C

TOXIC EFFECTS :: Liver - other changes Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,577,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10500 mg/kg/5W-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,559,1986

72491-93-1 structure

72491-93-1

~90%

72492-12-7 structure

72492-12-7

Literature: Kawada; Watanabe; Okamoto; Sugihara; Hirata; Maki; Imada; Sanno Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3532 - 3550

80901-29-7 structure

80901-29-7

~69%

72492-12-7 structure

72492-12-7

94243-45-5 structure

94243-45-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

16475-90-4 structure

16475-90-4

~%

72492-12-7 structure

72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

72492-92-3 structure

72492-92-3

~%

72492-12-7 structure

72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

80901-29-7 structure

80901-29-7

~%

72492-12-7 structure

72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

80901-29-7 structure

80901-29-7

~%

72492-12-7 structure

72492-12-7

94243-46-6 structure

94243-46-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

5061-21-2 structure

5061-21-2

16475-90-4 structure

16475-90-4

~%

72492-12-7 structure

72492-12-7

94243-46-6 structure

94243-46-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

Precursor 5
72491-93-1 80901-29-7 16475-90-4 72492-92-3
5061-21-2
DownStream 1
95449-94-8

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