SPIZOFURONE

Modify Date: 2024-01-08 09:34:18

SPIZOFURONE structure	Common Name	SPIZOFURONE
	CAS Number	72492-12-7	Molecular Weight	202.20600
	Density	1.33 g/cm3	Boiling Point	396.3ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₀O₃	Melting Point	150-155ºC
	MSDS	N/A	Flash Point	180.6ºC

Name	spizofurone
Synonym	More Synonyms

Density	1.33 g/cm3
Boiling Point	396.3ºC at 760 mmHg
Melting Point	150-155ºC
Molecular Formula	C₁₂H₁₀O₃
Molecular Weight	202.20600
Flash Point	180.6ºC
Exact Mass	202.06300
PSA	43.37000
LogP	1.99690
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9807500

CHEMICAL NAME :: Spiro(benzofuran-2(3H),1'-cyclopropan)-3-one, 5-acetyl-

CAS REGISTRY NUMBER :: 72492-12-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H10-O3

MOLECULAR WEIGHT :: 202.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5440 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 609 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1610 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1740 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1770 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,541,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 gm/kg/5W-C

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,547,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/26W-C

TOXIC EFFECTS :: Liver - other changes Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,577,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10500 mg/kg/5W-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 20,559,1986

5-acetyl-4',5'-...

CAS#:72491-93-1

~90%

SPIZOFURONE

CAS#:72492-12-7

Literature: Kawada; Watanabe; Okamoto; Sugihara; Hirata; Maki; Imada; Sanno Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3532 - 3550

α-(4-Acetyl-2-m...

CAS#:80901-29-7

~69%

SPIZOFURONE

CAS#:72492-12-7

N/A

CAS#:94243-45-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

Methyl 5-acetyl...

CAS#:16475-90-4

SPIZOFURONE

CAS#:72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

5-acetyl-2-((2-...

CAS#:72492-92-3

SPIZOFURONE

CAS#:72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

α-(4-Acetyl-2-m...

CAS#:80901-29-7

SPIZOFURONE

CAS#:72492-12-7

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3532 - 3550

α-(4-Acetyl-2-m...

CAS#:80901-29-7

SPIZOFURONE

CAS#:72492-12-7

N/A

CAS#:94243-46-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

3-Bromdihydrofu...

CAS#:5061-21-2

Methyl 5-acetyl...

CAS#:16475-90-4

SPIZOFURONE

CAS#:72492-12-7

N/A

CAS#:94243-46-6

Literature: Chemical and Pharmaceutical Bulletin, , vol. 32, # 9 p. 3373 - 3377

Precursor 5
CAS#:72491-93-1 5-acetyl-4',5'-... CAS#:80901-29-7 α-(4-Acetyl-2-m... CAS#:16475-90-4 Methyl 5-acetyl... CAS#:72492-92-3 5-acetyl-2-((2-...
CAS#:5061-21-2 3-Bromdihydrofu...
DownStream 1
CAS#:95449-94-8 [(Z)-(5-acetyls...

Maon

AG-629

5-acetylspiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

Espizofurona [spanish]

Spizofuronum

5-acetylspiro<benzofuran-2(3H),1'-cyclopropan>-3-one

Espizofurona

1'-cyclopropane]-3-one

5-acetylspiro[benzo[b]furan-2(3H)

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: SPIZOFURONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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SPIZOFURONE

Names

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms