73771-04-7

73771-04-7 structure

Name: Prednicarbate
Chemical Name: [2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate
CAS Number: 73771-04-7
Molecular Formula: C₂₇H₃₆O₈
Molecular Weight: 488.570
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-08-28 12:57:09
Modify Date: 2024-01-05 19:27:32
Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis[1][2].

Name	[2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate
Synonyms	(11b)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate propanoate de 2-{(8S,9S,10R,11S,13S,14S,17R)-17-[(éthoxycarbonyl)oxy]-11-hydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl}-2-oxoéthyle 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 17-(Ethyl Carbonate) 21-Propionate 2-{(8S,9S,10R,11S,13S,14S,17R)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl}-2-oxoethylpropanoat Dermatop 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 17-(ethyl carbonate) 21-propionate 2-{(8S,9S,10R,11S,13S,14S,17R)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl}-2-oxoethyl propanoate (11β)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propanoate Carbonic acid, ethyl (11β)-11-hydroxy-3,20-dioxo-21-(1-oxopropoxy)pregna-1,4-dien-17-yl ester Pregna-1,4-diene-3,20-dione, 17-((ethoxycarbonyl)oxy)-11-hydroxy-21-(1-oxopropoxy)-, (11β)- Prednicarbate (200 mg) Regemt Prednicarbate HOE-777 S 77 0777 Prednisolone 17-(ethyl carbonate) 21-propionate Regenit Prednitop S-77-0777 Prednisolone 17-Ethylcarbonate 21-Propionate

Description	Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Prednicarbate (0.25%; applied daily to the ear skin area for 2 days) recovers the 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis of mice[2].
References	[1]. Lubach D, et, al. Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin. Skin Pharmacol. 1988;1(3):200-6. [2]. Lee KH, et, al. Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice. J Pharm Pharmacol. 2014 Mar;66(3):466-76.

Density	1.3±0.1 g/cm3
Boiling Point	640.7±55.0 °C at 760 mmHg
Melting Point	110 - 112ºC
Molecular Formula	C₂₇H₃₆O₈
Molecular Weight	488.570
Flash Point	209.4±25.0 °C
Exact Mass	488.241028
PSA	116.20000
LogP	4.02
Vapour Pressure	0.0±4.3 mmHg at 25°C
Index of Refraction	1.560

RIDADR	NONH for all modes of transport

104286-02-4

123-62-6

~30%

73771-04-7

Literature: Stache; Fritsch; Rupp; Hitzel; Fehlhaber Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 12 p. 1753 - 1757

50-24-8

73771-04-7

Literature: Arzneimittel-Forschung/Drug Research, , vol. 35, # 12 p. 1753 - 1757

26129-79-3

73771-04-7

Literature: Arzneimittel-Forschung/Drug Research, , vol. 35, # 12 p. 1753 - 1757

79-03-8

104286-02-4

73771-04-7

Literature: Arzneimittel-Forschung/Drug Research, , vol. 35, # 12 p. 1753 - 1757

Precursor 4
104286-02-4 123-62-6 50-24-8 79-03-8
DownStream 2
5740-62-5 104286-02-4