56353-15-2

56353-15-2 structure

Name: Acetylcarnosine
Chemical Name: N-acetylcarnosine
CAS Number: 56353-15-2
Molecular Formula: C₁₁H₁₆N₄O₄
Molecular Weight: 268.269
Catalog: Biochemical Amino acids and their derivatives Other protected amino acids
Create Date: 2018-08-25 23:12:16
Modify Date: 2024-01-02 09:32:32
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in treatment of human cataracts[1].

Name	N-acetylcarnosine
Synonyms	(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid N-Acetyl-β-alanyl-L-histidine L-Histidine, N-acetyl-β-alanyl- Acetylcarnosine N-ACETYL-L-CARNOSINE N-Aceyl-L-Carnosine

Description	N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic drug in treatment of human cataracts[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Right eyes of the rabbits (male grey chinchilla rabbits aged 3-4 months weighing 2-3 k) are instilled with 80 μL of formulation A containing 1 % N-Acetylcarnosine. The N-Acetylcarnosine prodrug eye drops optimize the clinical effects for the treatment of ophthalmic disorders (such as prevention and reversal of cataracts in human and animal eyes)[1].
References	[1]. Babizhayev MA, et al. N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts. Peptides. 2001 Jun;22(6):979-94. [2]. Dubois VD, et al. N-acetylcarnosine (NAC) drops for age-related cataract. Cochrane Database Syst Rev. 2017 Feb 28;2:CD009493. [3]. Babizhayev MA, et al. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases. Drug Metabol Drug Interact. 2009;24(2-4):275-323.

Density	1.3±0.1 g/cm3
Boiling Point	775.9±60.0 °C at 760 mmHg
Melting Point	253 - 260ºC
Molecular Formula	C₁₁H₁₆N₄O₄
Molecular Weight	268.269
Flash Point	423.0±32.9 °C
Exact Mass	268.117157
PSA	124.18000
LogP	-2.56
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.563
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Hazard Codes	Xi
HS Code	2942000000

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%