134-05-4

134-05-4 structure

Name: 10-formylfolic acid (25 mg)
Chemical Name: (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
CAS Number: 134-05-4
Molecular Formula: C₂₀H₁₉N₇O₇
Molecular Weight: 469.40800
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-04-26 08:00:00
Modify Date: 2024-01-09 07:18:04
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

Name	(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
Synonyms	10-Formylpteroylglutamic Acid 10-Formylfolic acid N10-Formylfolic Acid

Description	10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
References	[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9. [2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

RIDADR	NONH for all modes of transport