10-formylfolic acid (25 mg)

Modify Date: 2024-01-09 07:18:04

10-formylfolic acid (25 mg) structure	Common Name	10-formylfolic acid (25 mg)
	CAS Number	134-05-4	Molecular Weight	469.40800
	Density	1.67g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₉N₇O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 10-formylfolic acid (25 mg)

10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

Name	(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
Synonym	More Synonyms

Description	10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
References	[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9. [2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

Description

10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate

References

[1]. M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71(7):2736-9.

[2]. J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129(7):1315-8.

Density	1.67g/cm3
Molecular Formula	C₂₀H₁₉N₇O₇
Molecular Weight	469.40800
Exact Mass	469.13500
PSA	221.56000
LogP	1.11410
Index of Refraction	1.748

RIDADR	NONH for all modes of transport

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

J. Agric. Food Chem. 50(17) , 4760-8, (2002)

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of l...

Folate metabolism in man: the effect of malignant disease.

Br. J. Cancer 46(3) , 346-53, (1982)

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding inclu...

Applicability of alkyl-bonded ultra-pure silica stationary phases for gradient reversed-phase HPLC of folates with conventional and volatile buffers under highly aqueous conditions.

J. Sep. Sci. 29(6) , 889-904, (2006)

Applicability of several alkyl-bonded silica stationary phases was tested for gradient RP-HPLC of folates under highly aqueous conditions. High retention of folates was achieved on alternative phases ...

10-Formylpteroylglutamic Acid

10-Formylfolic acid

N10-Formylfolic Acid

10-formylfolic acid (25 mg)

Use of 10-formylfolic acid (25 mg)

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