380488-27-7

380488-27-7 structure

Name: 187-1, N-WASP inhibitor TFA
Chemical Name: 187-1, N-WASP inhibitor
CAS Number: 380488-27-7
Molecular Formula: C₉₆H₁₂₂N₁₈O₁₆
Molecular Weight: 1784.11000
Catalog: Signaling Pathways Cytoskeleton Arp2/3 Complex
Create Date: 2017-11-14 20:45:38
Modify Date: 2024-01-02 01:38:40
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].

Name	187-1, N-WASP inhibitor
Synonyms	n-wasp-inhibitor,187-1 m.w. 1784.13 c96h122n18o16

Description	187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Others
References	[1]. Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. [2]. S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J Biol Chem. 2001 Aug 31;276(35):33175-80.

Hazard Codes	Xi