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Related CAS#:
2078-54-8 525-66-6
258516-89-1 1261393-54-7
1189467-93-3 807333-52-4
1576-14-3 1988-15-4
1988-10-9 1988-11-0

2078-54-8

2078-54-8 structure
2078-54-8 structure
  • Name: Propofol
  • Chemical Name: propofol
  • CAS Number: 2078-54-8
  • Molecular Formula: C12H18O
  • Molecular Weight: 178.271
  • Catalog: API Anesthetic Agents General anesthetics
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 18:08:15
  • Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].
Name propofol
Synonyms 2,6-Bis(1-methylethyl)phenol (2,6-Bis(isopropyl)phenol
2,6-i-Pr2-C6H3-OH
Diisopropylphenol
2,6-di-iso-Propylphenol
2,6-di(propan-2-yl)phenol
Propofolum
Disoprofol
2-hydroxy-1,3-diisopropylbenzene
Fresofol
Diprivan
EINECS 218-206-6
Disoprivan
2,6-Diisopropylphenol
2,5-DIHYDRO-5-OXO-1-PHENYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID DIMETHYLAMIDE
MFCD00008885
Description Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].
Related Catalog
Target

GABAA[1]
In Vivo Propofol (i.p.; 40 mg/kg) causes full recovery from sedation occurred 36.3 mins. There is residual antinociception when assessed by ECT but not when assessed by noxious heat[1].
References

[1]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6.
Density 0.9±0.1 g/cm3
Boiling Point 256.0±0.0 °C at 760 mmHg
Melting Point 18 °C(lit.)
Molecular Formula C12H18O
Molecular Weight 178.271
Flash Point 107.5±7.2 °C
Exact Mass 178.135757
PSA 20.23000
LogP 4.16
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.513
Storage condition 0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL0810000
CHEMICAL NAME :
Phenol, 2,6-diisopropyl-
CAS REGISTRY NUMBER :
2078-54-8
BEILSTEIN REFERENCE NO. :
1866484
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H18-O
MOLECULAR WEIGHT :
178.30
WISWESSER LINE NOTATION :
QR BY1&1 FY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
386 mg/kg/14D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
CCMDC7 Critical Care Medicine. (Williams & Wilkins, 428 E. Preston Street, Baltimore, MD 21202) V.1- 1973- Volume(issue)/page/year: 23,1928,1995
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2857 ug/kg/1D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - rigidity (including catalepsy) Behavioral - irritability
REFERENCE :
ANASAB Anaesthesia. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1946- Volume(issue)/page/year: 43,170,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,953,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 21,11,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,953,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 2,201,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Behavioral - analgesia
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - sleep Behavioral - muscle weakness
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1350,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
2800 ug/kg
SEX/DURATION :
female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - behavioral
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year: 62,649,1989
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36/37/39-S37/39
RIDADR 2810
WGK Germany 3
RTECS SL0810000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2907199090
HS Code 2907199090
Summary 2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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