Name | propofol |
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Synonyms |
2,6-Bis(1-methylethyl)phenol (2,6-Bis(isopropyl)phenol
2,6-i-Pr2-C6H3-OH Diisopropylphenol 2,6-di-iso-Propylphenol 2,6-di(propan-2-yl)phenol Propofolum Disoprofol 2-hydroxy-1,3-diisopropylbenzene Fresofol Diprivan EINECS 218-206-6 Disoprivan 2,6-Diisopropylphenol 2,5-DIHYDRO-5-OXO-1-PHENYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID DIMETHYLAMIDE MFCD00008885 |
Description | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1]. |
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Related Catalog | |
Target |
GABAA[1] |
In Vivo | Propofol (i.p.; 40 mg/kg) causes full recovery from sedation occurred 36.3 mins. There is residual antinociception when assessed by ECT but not when assessed by noxious heat[1]. |
References |
Density | 0.9±0.1 g/cm3 |
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Boiling Point | 256.0±0.0 °C at 760 mmHg |
Melting Point | 18 °C(lit.) |
Molecular Formula | C12H18O |
Molecular Weight | 178.271 |
Flash Point | 107.5±7.2 °C |
Exact Mass | 178.135757 |
PSA | 20.23000 |
LogP | 4.16 |
Vapour Pressure | 0.0±0.5 mmHg at 25°C |
Index of Refraction | 1.513 |
Storage condition | 0-6°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H302-H315-H319-H335 |
Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Hazard Codes | Xn:Harmful |
Risk Phrases | R22;R36/37/38 |
Safety Phrases | S26-S36/37/39-S37/39 |
RIDADR | 2810 |
WGK Germany | 3 |
RTECS | SL0810000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2907199090 |
Precursor 8 | |
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DownStream 10 | |
HS Code | 2907199090 |
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Summary | 2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |