Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: D-erythro-sphingosine-1-phosphate
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26993-30-6

26993-30-6 structure

Name: Sphingosine-1-phosphate
Chemical Name: sphingosine 1-phosphate
CAS Number: 26993-30-6
Molecular Formula: C₁₈H₃₈NO₅P
Molecular Weight: 379.472
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2018-07-16 19:54:13
Modify Date: 2026-07-13 00:10:06
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].

Name	sphingosine 1-phosphate
Synonyms	SPHINGOSINE-1-PHOSPHORIC ACID D-erythro-Sphingosin-1-phosphate Sphing-4-enine 1-phosphate SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO (E)-D-ERYTHRO-2-AMINO-1-(DIHYDROGENPHOSPHATE)-4-OCTADECENE-1,3-DIOL D-erythro Sphingosine-1-phosphate, agonist of S1P rectors 4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt C18-Sphingosine 1-phosphate (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate) Sphingosine 1-phosphate MFCD00274457 35 kDa pulmony surfactant-associated protein S1P (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate D-erythro-Sphingosine-1-phosphate D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE (2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate Somatostatin 1-28 SFTPA1B (4E)-2-Amino-3-hydroxy-4-octadecen-1-yl dihydrogen phosphate (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate D-erythro-Sphingosine-1-phosphate - - Calbiochem (4E)-2-Amino-3-hydroxy-4-octadecen-1-yldihydrogen-phosphat (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate D-erythro-Sphingosine 1-phosphate [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate Sphingosine-1-phosphate (d18:1) Alveolproteinosis protein D-erythro-sphingosine-1-phosphate Dihydrogène phosphate de (4E)-2-amino-3-hydroxy-4-octadécèn-1-yle SPN-1-P Mouse Sphingosine-1-phosphate elisa kit (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid 1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), D-erythro- (8C I) SPHINGOSINE-1-PHOSPHATE Sphingosine 1-phosphic acid Quetiapine Impurity 54-d8 (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate,D-erythro-Sphingosine 1-phosphate D-erythro-Sphingosine 1-phosphate SHINGOSINE-1-PHOSPHATE \ EDG-1 RECTOR (4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate SPHINGOSINE-1-PO4 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E) 1-SPP Collectin-4

Description	Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> LPL Receptor
Target	Human Endogenous Metabolite
In Vitro	S1P (1 μM) induces a significant Ca2+ releases in HEK293 cells under serum starvation conditions (1% FCS)[1]. In a functional Ca2+ assay, Suramin (HY-B0879) alone does not exert any effect on intracellular Ca2+ release via gpr3, gpr6 or gpr12. In contrast, S1P (1 μM) induces Ca2+ release of gpr3, gpr6 and gpr12 in the presence of Suramin (HY-B0879) various concentrations in transfected HEK293 cells[2]. In a functional Ca2+ assay,S1P (3-3000 nM) in the presence Suramin (300 μM), exhibits nanomolar EC50 values for gpr3 (EC50=29 nM), gpr6 (EC50=15 nM) and gpr12 (EC50=24 nM), rat gpr3 (EC50=68 nM),respectively in HEK293 cells[2]. S1P increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively)[3].
References	[1]. Teresa Sanchez, et al. Structural and Functional Characteristics of S1P Receptors. J Cell Biochem. 2004 Aug 1;92(5):913-22. [2]. Kirsten Uhlenbrock, et al. Sphingosine 1-phosphate Is a Ligand of the Human gpr3, gpr6 and gpr12 Family of Constitutively Active G Protein-Coupled Receptors. Cell Signal. 2002 Nov;14(11):941-53. [3]. S An, et al. Transduction of Intracellular Calcium Signals Through G Protein-Mediated Activation of Phospholipase C by Recombinant Sphingosine 1-phosphate Receptors. Mol Pharmacol. 1999 May;55(5):787-94

Density	1.1±0.1 g/cm3
Boiling Point	548.8±60.0 °C at 760 mmHg
Melting Point	190ºC
Molecular Formula	C₁₈H₃₈NO₅P
Molecular Weight	379.472
Flash Point	285.7±32.9 °C
Exact Mass	379.248749
PSA	122.82000
LogP	5.46
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.501
Storage condition	−20°C
Stability	Moisture, Temperature Sensitive; Hygroscopic
Water Solubility	methanol: THF: water (6:3:1): >0.5 mg/mL

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2922509090

Precursor 6
860021-47-2 116467-63-1 207516-26-5 114299-64-8
137905-29-4 149035-77-8
DownStream 1
1093733-24-4

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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