147782-19-2

147782-19-2 structure

Name: DCG IV
Chemical Name: DCG IV,(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
CAS Number: 147782-19-2
Molecular Formula: C₇H₉NO₆
Molecular Weight: 203.14900
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2018-12-25 20:23:37
Modify Date: 2024-01-06 01:27:27
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

Name	DCG IV,(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
Synonyms	dcg iv

Description	DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vitro	DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].
In Vivo	DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4]. Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4] Dosage: 10, 5, or 1 mg/kg Administration: I.p. Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
References	[1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. [2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30. [4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91.

Density	1.819 g/cm3
Boiling Point	503.9ºC at 760 mmHg
Molecular Formula	C₇H₉NO₆
Molecular Weight	203.14900
Flash Point	258.5ºC
Exact Mass	203.04300
PSA	137.92000
Vapour Pressure	1.61E-11mmHg at 25°C
Index of Refraction	1.643

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