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51411-04-2

51411-04-2 structure
51411-04-2 structure
  • Name: Alrestatin
  • Chemical Name: 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
  • CAS Number: 51411-04-2
  • Molecular Formula: C14H9NO4
  • Molecular Weight: 168.042
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
  • Create Date: 2018-02-12 08:00:00
  • Modify Date: 2024-01-04 09:55:02
  • Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

Name 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid
Synonyms Alrestatine
2,3-Dioxopropyl dihydrogen phosphate
Propanal, 2-oxo-3-(phosphonooxy)-
alrestatin
Description Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
Related Catalog
Density 1.7±0.1 g/cm3
Boiling Point 359.1±44.0 °C at 760 mmHg
Molecular Formula C14H9NO4
Molecular Weight 168.042
Flash Point 171.0±28.4 °C
Exact Mass 167.982376
PSA 76.37000
LogP -2.47
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.480
Storage condition -20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE4080500
CHEMICAL NAME :
1H-Benz(de)isoquinoline-2(3H)-acetic acid, 1,3-dioxo-
CAS REGISTRY NUMBER :
51411-04-2
BEILSTEIN REFERENCE NO. :
0244370
LAST UPDATED :
199703
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C14-H9-N-O4
MOLECULAR WEIGHT :
255.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4405625
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4118495
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4118495
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%