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Product Name: H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2
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135306-85-3

135306-85-3 structure

135306-85-3 structure

Name: (Tyr5,D-Trp6.8.9,Lys-NH2¹⁰)-Neurokinin A (4-10)
Chemical Name: asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2
CAS Number: 135306-85-3
Molecular Formula: C₅₇H₆₈N₁₂O₁₀
Molecular Weight: 1081.22000
Catalog: Peptides
Create Date: 2018-12-29 20:25:02
Modify Date: 2026-07-03 12:14:33
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.

Name	asp-tyr-d-trp-val-d-trp-d-trp-lys-nh2
Synonyms	[TYR5,D-TRP6,8 9,LYS10]-ALPHA-NEUROKININ A FRAGMENT (Tyr5,D-Trp6.8.9,Lys-NH1)-Neurokinin A L-Lysinamide, L-α-asptyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl MEN-10,376 , (HPLC) MEN-10,376, (HPLC) NK2 TACHYKININ RECEPT [TYR5, D-TRP6,8,9, LYS10]NEUROKININ A MEN-10,376 L-Asp-L-Tyr-D-Trp-L-Val-D-Trp-D-Trp-L-Lys-NH2 M.W. 1081.24 C57H68N12O10 Men 10376 3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropa tyr(5)-trp(6,8,9)-lys-neurokinina( (Tyr,D-Trp··,Lys-NH)-Neurokinin A L-Lysinamide, L-a-asptyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl (TYR5,D-TRP6·8·9,LYS-NH210)-NEUROKININ A (4-10) L-alpha-Asptyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-lysinamide (Tyr5,D-Trp6·8·9,Lys-NH210)-Neurokinin A MEN (Tyr5,D-Trp6.8.9,Lys-NH21)-Neurokinin A (TYR5,D-TRP6,8,9,LYS-NH(2/10))-NEUROKININ A ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2 3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid neurokinin A, Tyr(5)-Trp(6,8,9)-Lys MEN-10,376 SYNTHETIC NK2 TACHYKININ RECT alpha-neurokinin, fragment , [Tyr5, Trp6,8,9, Lys10] [TYR5 ,D -TRP6,8 9 ,LYS10 ]-ALPHA-NEUROKININ A FRAGMENT (tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment H-ASP-TYR-D-TRP-VAL-D-TRP-D-TRP-LYS-NH2 C57H68N12O10 Neurokinin-2 rector antagonist

Description	Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Peptides Research Areas >> Others
Target	Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]
In Vitro	Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
In Vivo	Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
References	[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.

Density	1.361 g/cm3
Boiling Point	1555.4ºC at 760 mmHg
Molecular Formula	C₅₇H₆₈N₁₂O₁₀
Molecular Weight	1081.22000
Flash Point	894.5ºC
Exact Mass	1080.52000
PSA	374.63000
LogP	6.53410
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.672
Storage condition	-20°C
Water Solubility	Insuluble (2.3E-3 g/L) (25 ºC)

Hazard Codes	N
RIDADR	NONH for all modes of transport
WGK Germany	3.0

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