6266-99-5

6266-99-5 structure

Name: SIB 1893
Chemical Name: SIB 1893,2-Methyl-6-(2-phenylethenyl)pyridine
CAS Number: 6266-99-5
Molecular Formula: C₁₄H₁₃N
Molecular Weight: 195.26000
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2017-09-29 02:34:34
Modify Date: 2025-08-27 18:49:24
(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist[1].

Name	SIB 1893,2-Methyl-6-(2-phenylethenyl)pyridine

Description	(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
In Vivo	(E)-SIB-1893 produces hypothermia in freely moving rats in a dose-dependent manner[1].
References	[1]. Łuszczki JJ, et al. Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. Pharmacol Rep. 2005;57(6):795-801.