95167-41-2
95167-41-2 structure
- Name: DY131
- Chemical Name: DY131
- CAS Number: 95167-41-2
- Molecular Formula: C18H21N3O2
- Molecular Weight: 311.378
- Catalog: Research Areas Cancer
- Create Date: 2017-03-27 14:35:49
- Modify Date: 2024-01-07 18:19:49
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DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.IC50 value:Target: ERRβ/γDY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.
| Name | DY131 |
|---|---|
| Synonyms |
Benzoic acid, 4-hydroxy-, 2-[(1E)-[4-(diethylamino)phenyl]methylene]hydrazide
N'-{(E)-[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide N'-{(E)-[4-(Diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide Benzoic acid, 4-hydroxy-, [[4-(diethylamino)phenyl]methylene]hydrazide (9CI) N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine GSK 9089 |
| Description | DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.IC50 value:Target: ERRβ/γDY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H21N3O2 |
| Molecular Weight | 311.378 |
| Exact Mass | 311.163391 |
| PSA | 64.93000 |
| LogP | 3.17 |
| Index of Refraction | 1.574 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| HS Code | 2928000090 |
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95167-41-2 |
| Literature: Forman, Barry; Yu, Donna Patent: US2006/189825 A1, 2006 ; Location in patent: Page/Page column 7; 12; Sheet 3/7 ; US 20060189825 A1 |
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95167-41-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1311 - 1313 |
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95167-41-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1311 - 1313 |
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95167-41-2 |
| Literature: Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3107 - 3109 |
| HS Code | 2928000090 |
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| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |