335165-68-9

335165-68-9 structure

Name: Bax channel blocker
Chemical Name: 1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol,dihydrochloride
CAS Number: 335165-68-9
Molecular Formula: C₁₉H₂₃Br₂Cl₂N₃O
Molecular Weight: 540.11900
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2018-12-14 00:13:17
Modify Date: 2025-08-24 17:18:11
BAI1 is a direct allosteric inhibitor of BAX.

Name	1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol,dihydrochloride
Synonyms	Bax channel blocker

Description	BAI1 is a direct allosteric inhibitor of BAX.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	BAX[1]
References	[1]. Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330.

Boiling Point	388.1ºC at 760 mmHg
Molecular Formula	C₁₉H₂₃Br₂Cl₂N₃O
Molecular Weight	540.11900
Flash Point	188.5ºC
Exact Mass	536.95800
PSA	40.43000
LogP	5.45630
Storage condition	2-8℃

HS Code	2933990090

335165-75-8

~10%

335165-68-9

Literature: Applied Research Systems ARS Holding N.V. Patent: EP1094063 A1, 2001 ;

335165-74-7

~96%

335165-68-9

Literature: Applied Research Systems ARS Holding N.V. Patent: EP1094063 A1, 2001 ;

335165-67-8

335165-68-9

Literature: Bombrun, Agnes; Gerber, Patrick; Casi, Giulio; Terradillos, Olivier; Antonsson, Bruno; Halazy, Serge Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4365 - 4368

6825-20-3

335165-68-9

Literature: Bombrun, Agnes; Gerber, Patrick; Casi, Giulio; Terradillos, Olivier; Antonsson, Bruno; Halazy, Serge Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4365 - 4368

159873-06-0

335165-68-9

Literature: Bombrun, Agnes; Gerber, Patrick; Casi, Giulio; Terradillos, Olivier; Antonsson, Bruno; Halazy, Serge Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4365 - 4368

Precursor 5
335165-75-8 335165-74-7 335165-67-8 6825-20-3
159873-06-0
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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