Name | 2-[[4-[1-(2,4-diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid |
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Synonyms |
10-EdAM
10-ethyl-10-deazaaminopterin EDATREXATE |
Description | Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate (HY-14519) analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch of non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and cancer of the head and neck[1][2]. |
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Related Catalog | |
In Vivo | Edatrexate (0.14 g/kg and 0.21 g/kg; i.p.; twice weekly×3 or weekly×3) exerts potent efficacy against advanced metastatic disease in tumor-bearing mice, better than MTX[1]. Animal Model: Murine models of advanced metastatic disease (including E0771 mammary adenocarcinoma, T241 fibrosarcoma, Lewis lung carcinoma, B16 melanoma, or C38 colon carcinoma)[2] Dosage: 0.14 g/kg and 0.21 g/kg Administration: Intraperitoneal injection; 0.14 g/kg twice weekly for 3 weeks and 0.21 g/kg weekly for 3 weeks; added Ca leucovorin (LCV) 16, 20, 24 h after Edatrexate treatment Result: Increased survival of tumor-bearing mice. Showed markedly therapeutic effectiveness against advanced metastatic disease in high-dose regimen with delayed LCV rescue. |
Density | 1.441 g/cm3 |
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Molecular Formula | C22H25N7O5 |
Molecular Weight | 467.47800 |
Exact Mass | 467.19200 |
PSA | 207.30000 |
LogP | 2.92160 |
Index of Refraction | 1.686 |
~88% 80576-83-6 |
Literature: Piper; Johnson; Otter; Sirotnak Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3002 - 3006 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 35, # 16 p. 3002 - 3006 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1227 - 1230 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1227 - 1230 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1227 - 1230 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1227 - 1230 |
~% 80576-83-6 |
Literature: Journal of Medicinal Chemistry, , vol. 35, # 16 p. 3002 - 3006 |
Precursor 5 | |
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DownStream 0 |