19088-73-4
19088-73-4 structure
- Name: 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE
- Chemical Name: 3-Cyanoumbelliferone
- CAS Number: 19088-73-4
- Molecular Formula: C10H5NO3
- Molecular Weight: 187.15200
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyran compound
- Create Date: 2018-06-12 09:46:14
- Modify Date: 2024-01-08 16:16:16
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3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM[1].
| Name | 3-Cyanoumbelliferone |
|---|---|
| Synonyms |
3-Cyano-7-hydroxycoumarin
7-hydroxy-2-oxochromene-3-carbonitrile 7-Hydroxy-2-oxo-2H-chromene-3-carbonitrile |
| Description | 3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 2.9 μM (MIF)[1] |
| References |
| Density | 1.5 g/cm3 |
|---|---|
| Boiling Point | 436.6ºC at 760 mmHg |
| Melting Point | ≥250ºC(lit.) |
| Molecular Formula | C10H5NO3 |
| Molecular Weight | 187.15200 |
| Flash Point | 217.8ºC |
| Exact Mass | 187.02700 |
| PSA | 74.23000 |
| LogP | 1.37028 |
| Vapour Pressure | 3.13E-08mmHg at 25°C |
| Index of Refraction | 1.667 |
| Water Solubility | DMF: soluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332-H315-H319-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
|
~86%
19088-73-4 |
| Literature: Synthetic Communications, , vol. 35, # 6 p. 785 - 790 |
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~84%
19088-73-4 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 48, # 4 p. 799 - 802 |
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| Literature: Organic Letters, , vol. 13, # 19 p. 5260 - 5263 |
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~92%
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| Literature: Journal of Heterocyclic Chemistry, , vol. 46, # 6 p. 1392 - 1395 |
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| Literature: Synthesis, , # 15 p. 2331 - 2334 |
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19088-73-4 |
| Literature: Acta Pharmacologica Sinica, , vol. 34, # 11 p. 1437 - 1448 |
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19088-73-4 |
| Literature: Archives of Biochemistry and Biophysics, , vol. 505, # 2 p. 186 - 193 |
| Precursor 6 | |
|---|---|
| DownStream 2 | |
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |