Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Thymine-beta-D-arabinofuranoside
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Purity: 98.0%
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605-23-2

605-23-2 structure

Name: Thymine-beta-D-arabinofuranoside
Chemical Name: 1-.β.-D-Arabinofuranosylthymine
CAS Number: 605-23-2
Molecular Formula: C₁₀H₁₄N₂O₆
Molecular Weight: 258.23
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-12-31 12:59:14
Modify Date: 2026-07-03 17:58:16
Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-.β.-D-Arabinofuranosylthymine
Synonyms	Thymine 1-β-D-abinofuranoside 1--D-abinofuranosyl-5-methyl-(1H,3H)-pyrimidine-2,4-dione EINECS 210-083-7 5-methyl-a-Ur 5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione 1-BETA-D-ABINOFURANOSYLTHYMINE Arabinofuranosylthymine Thymine 1-β-Dabinofuranoside thymine 1-B-D-abinofuranoside thymineabinoside THYMINE-BETA-D-ABINOFURANOSIDE //BP 1-β-D-abinofuranos 1-(β-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione a-Tr spongothymidine thymine arabinoside ARABINOFURANOSYL-5-METHYLURACIL 5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione Thymine abinofuranoside 1-β-D-abinofuranosylthymine 1-(β-D-abinofuranosyl)thymine GS1999FULL 3h)-pyrimidinedione,1-beta-d-abinofuranosyl-5-methyl-4(1h 1-beta-d-abinofuranosyl-thymin 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione Thymine 1-beta-D-abinofuranoside >= abinofuranosyl-5-methyluridine, antiviral and immune-suppressive agents 1-B-D-abinofuranosylthymine THYMINE-BETA-D-ABINOFURANOSIDE 1-beta-D-abinofuranosylthymine, a-T Thymine arabinofuranoside 2,4(1H,3H)-Pyrimidinedione, 1-β-D-abinofuranosyl-5-methyl abinofuranosyl-5-methyluracil, Thymine 1-β-D- abinofuranoside MFCD00065474 A-T 1-(β-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion THYMINE 1-BETA-D-ABINOFURANOSIDE 5-Me-a-U ARA-T abinofuranosylthymine 1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione 1-β-D-abinofuranosyl-5-methylpyrimidine-2,4(1H,3H)-dione 1-B-D-Arabinofuranosylthymine spongothymidin Thymine 1-beta-D-arabinofuranoside 1-beta-D-abinofuranosyl-5-methyl-(1H,3H)-pyrimidine-2,4-dione abinofuranosyl-5-methyluridine THYMIN-BETA-D-ABINOFURANOSIDE Thymine 1-β-D-abinofuranoside\|\|\|Spongothymidine ABINOFURANOSYL-5-METHYLURACIL Thymine 1-β- D -abinofuranoside 1-β-D-abinofuranosyl-5-methyl-2,4(1H,3H)-pyrimidinedione 1-abinofuranosylthymine abinosylthymine 1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1-β-D-Arabinofuranosylthymine arabinosylthymine

Description	Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₀H₁₄N₂O₆
Molecular Weight	258.23
Exact Mass	258.085175
PSA	124.78000
LogP	-1.02
Index of Refraction	1.619
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP2100200

CHEMICAL NAME :: Thymine, 1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 605-23-2

BEILSTEIN REFERENCE NO. :: 0090166

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H14-N2-O6

MOLECULAR WEIGHT :: 258.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 7100 ug/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 23,141,1978

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	XP2100200

Precursor 9
1463-10-1 88054-44-8 22423-26-3 25545-03-3
27963-98-0 65-71-4 3083-77-0 88054-41-5
6974-32-9
DownStream 1
117626-85-4

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