Thymine-beta-D-arabinofuranoside
Thymine-beta-D-arabinofuranoside structure
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Common Name | Thymine-beta-D-arabinofuranoside | ||
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| CAS Number | 605-23-2 | Molecular Weight | 258.23 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H14N2O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Thymine-beta-D-arabinofuranosideThymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1-.β.-D-Arabinofuranosylthymine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Thymine 1-β-D-arabinofuranoside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| Exact Mass | 258.085175 |
| PSA | 124.78000 |
| LogP | -1.02 |
| Index of Refraction | 1.619 |
| InChIKey | DWRXFEITVBNRMK-JAGXHNFQSA-N |
| SMILES | Cc1cn(C2OC(CO)C(O)C2O)c(=O)[nH]c1=O |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XP2100200 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
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| DownStream 1 | |
CAS#:1463-10-1![2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyl-5-[[(4-methylphenyl)thio]methyl] Structure](https://image.chemsrc.com/caspic/337/88054-44-8.png)
CAS#:88054-44-8
CAS#:22423-26-3
CAS#:25545-03-3![Furo[2,3-d]oxazole-5-methanol,2-amino-3a,5,6,6a-tetrahydro-6-hydroxy-, (3aR,5R,6R,6aS) Structure](https://image.chemsrc.com/caspic/482/27963-98-0.png)
CAS#:27963-98-0
CAS#:65-71-4
CAS#:3083-77-0
CAS#:88054-41-5
CAS#:6974-32-9![2-[[5-(2-amino-3-methyl-6-oxo-2,5-dihydro-1H-pyridin-5-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]acetic acid structure](https://image.chemsrc.com/caspic/462/117626-85-4.png)
CAS#:117626-85-4This table lists relevant public references with title, journal and publication metadata for this compound.
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Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model.
Nanomedicine: Nanotechnology, Biology, and Medicine 11 , 1345-54, (2015) Liposomal drug delivery vehicles are promising nanomedicine tools for bringing cytotoxic drugs to cancerous tissues selectively. However, the triggered cargo release from liposomes in response to a ta... |
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Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade.
Sci. Transl. Med. 7 , 315ra188, (2015) Targeted drug delivery with antibody-drug conjugates such as the HER2-directed ado-trastuzumab emtansine (T-DM1) has emerged as a powerful strategy for cancer therapy. We show that T-DM1 is particular... |
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iTRAQ-Based Quantitative Proteomic Analysis of Tear Fluid in a Rat Penetrating Keratoplasty Model With Acute Corneal Allograft Rejection.
Invest. Ophthalmol. Vis. Sci. 56 , 4117-24, (2015) This study aimed to develop a greater understanding of the mechanisms underlying acute corneal allograft rejection by identifying differentially expressed tear proteins at defined stages and discoveri... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Ability to reduce plaque formation of herpes simplex virus type 1 (HSV-1) by 50% in h...
Source: ChEMBL
Target: Human alphaherpesvirus 1
External Id: CHEMBL689480
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Name: Inhibitory concentration against Drosophila melanogaster deoxyribonucleoside kinase (...
Source: ChEMBL
Target: Deoxynucleoside kinase
External Id: CHEMBL663661
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Name: Cytotoxicity against mouse L1210 cells at 400 uM after 1 day
Source: ChEMBL
Target: L1210
External Id: CHEMBL3254536
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Name: Cytotoxicity against mouse S180 cells at 400 uM after 1 day
Source: ChEMBL
Target: CCRF S-180
External Id: CHEMBL3254535
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Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL3579569
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Name: Inhibition of human TK1 assessed as [methyl-3H]dThd phosphorylation
Source: ChEMBL
Target: Thymidine kinase, cytosolic
External Id: CHEMBL886766
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Name: Inhibition of human TK2 assessed as [methyl-3H]dThd phosphorylation
Source: ChEMBL
Target: Thymidine kinase 2, mitochondrial
External Id: CHEMBL886767
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Name: Antiviral activity against thymidine kinase activity from K562 mammalian cells at 500...
Source: ChEMBL
Target: Thymidine kinase, cytosolic
External Id: CHEMBL812476
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Name: Anti-HIV activity in H9 cell line; Not active
Source: ChEMBL
Target: H9
External Id: CHEMBL683842
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Name: Antiviral activity against thymidine kinase from Herpes simplex virus type-2 (333 Str...
Source: ChEMBL
Target: Thymidine kinase, cytosolic
External Id: CHEMBL812478
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Thymine arabinofuranoside |
| 1-(β-D-Arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione |
| spongothymidine |
| thymine arabinoside |
| ARABINOFURANOSYL-5-METHYLURACIL |
| EINECS 210-083-7 |
| MFCD00065474 |
| 1-(β-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione |
| 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidindion |
| 5-Methyl-1-pentofuranosyl-2,4(1H,3H)-pyrimidinedione |
| ARA-T |
| 5-Methyl-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione |
| 1-[3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-5-méthyl-2,4(1H,3H)-pyrimidinedione |
| 1-B-D-Arabinofuranosylthymine |
| spongothymidin |
| Arabinofuranosylthymine |
| 1-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione |
| Thymine 1-beta-D-arabinofuranoside |
| 1-β-D-Arabinofuranosylthymine |
| arabinosylthymine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of 1-.β.-D-Arabinofuranosylthymine? |
| A: Related downstream products(CAS) of 1-.β.-D-Arabinofuranosylthymine: 117626-85-4. |
| Q: What is the polar surface area (PSA) of 1-.β.-D-Arabinofuranosylthymine? |
| A: Polar surface area (PSA) of 1-.β.-D-Arabinofuranosylthymine is 124.78000. |
| Q: What is the CAS number of 1-.β.-D-Arabinofuranosylthymine? |
| A: CAS number of 1-.β.-D-Arabinofuranosylthymine is 605-23-2. |
| Q: What are the upstream materials of 1-.β.-D-Arabinofuranosylthymine? |
| A: Related upstream materials(CAS) of 1-.β.-D-Arabinofuranosylthymine: 1463-10-1;88054-44-8;22423-26-3;25545-03-3;27963-98-0;65-71-4;3083-77-0;88054-41-5;6974-32-9. |
| Q: What is the InChIKey of 1-.β.-D-Arabinofuranosylthymine? |
| A: InChIKey of 1-.β.-D-Arabinofuranosylthymine is DWRXFEITVBNRMK-JAGXHNFQSA-N. |
| Q: What is the LogP of 1-.β.-D-Arabinofuranosylthymine? |
| A: LogP of 1-.β.-D-Arabinofuranosylthymine is -1.02. |
| Q: What is the molecular formula of 1-.β.-D-Arabinofuranosylthymine? |
| A: Molecular formula of 1-.β.-D-Arabinofuranosylthymine is C10H14N2O6. |
| Q: What is the molecular weight of 1-.β.-D-Arabinofuranosylthymine? |
| A: Molecular weight of 1-.β.-D-Arabinofuranosylthymine is 258.23. |
| Q: What is the English name of 1-.β.-D-Arabinofuranosylthymine? |
| A: The English name of 1-.β.-D-Arabinofuranosylthymine is 1-.β.-D-Arabinofuranosylthymine. |
| Q: What are the storage conditions for 1-.β.-D-Arabinofuranosylthymine? |
| A: Storage conditions for 1-.β.-D-Arabinofuranosylthymine: 2-8°C. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |