517-66-8

517-66-8 structure

Name: Dicentrine
Chemical Name: 9,10-Dimethoxy-1,2-(methylenedioxy)aporphine
CAS Number: 517-66-8
Molecular Formula: C₂₀H₂₁NO₄
Molecular Weight: 339.385
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-09 11:04:17
Modify Date: 2024-01-02 17:16:59
Dicentrine is a natural product isolated from the plant Lindera megaphylla with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates[1].

Name	9,10-Dimethoxy-1,2-(methylenedioxy)aporphine
Synonyms	(7aS)-10,11-Dimethoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline Dicentrine DICENTRINE- (+) 9,10-Dimethoxy-1,2-(methylenedioxy)-6aalpha-aporphine o,N-Dimethyllitseferine 5H-Benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-, (S)- d-Dicentrine (7aS)-6,7,7a,8-Tetrahydro-10,11-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline 1,2-(Methylenedioxy)-9,10-dimethoxy-6aalpha-aporphine 5H-1,3-Benzodioxolo[6,5,4-de]benzo[g]quinoline, 6,7,7a,8-tetrahydro-10,11-dimethoxy-7-methyl-, (7aS)- 1,2-Methylenedioxy-9,10-dimethoxyaporphine

Description	Dicentrine is a natural product isolated from the plant Lindera megaphylla with antihypertensive effect. Dicentrine is an α1-adrenoceptor antagonist which has effective against human hyperplastic prostates[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1-adrenoceptor[1]
References	[1]. Sheu-Meei Yu, et al. Effects of dicentrine, a novel α1-adrenoceptor antagonist, on human hyperplastic prostates. European Journal of Pharmacology. 1994 Jan; 252(1):29-34.

Density	1.3±0.1 g/cm3
Boiling Point	480.7±45.0 °C at 760 mmHg
Melting Point	177-178ºC
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.385
Flash Point	142.7±25.9 °C
Exact Mass	339.147064
PSA	40.16000
LogP	3.98
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.616

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE0455000

CHEMICAL NAME :: 6a-alpha-Aporphine, 9,10-dimethoxy-1,2-(methylenedioxy)-

CAS REGISTRY NUMBER :: 517-66-8

BEILSTEIN REFERENCE NO. :: 0095476

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N-O4

MOLECULAR WEIGHT :: 339.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,267,1990

72203-90-8

517-66-8

Literature: Vecchietti; Casagrande; Ferrari; Severini Ricca Farmaco, Edizione Scientifica, 1979 , vol. 34, # 10 p. 829 - 840

25394-59-6

74-88-4

517-66-8

Literature: Ghose et al. Helvetica Chimica Acta, 1934 , vol. 17, p. 919,929

186581-53-3

50-00-0

60142-18-9

517-66-8

Literature: Sivakumaran,M.; Gopinath,K.W. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 150 - 151

517-69-1

517-66-8

Literature: Ghose et al. Helvetica Chimica Acta, 1934 , vol. 17, p. 919,929

Precursor 6
517-69-1 25394-59-6 74-88-4 186581-53-3
50-00-0 60142-18-9
DownStream 1
19843-03-9

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