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Product Name: Sevoflurane
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28523-86-6

28523-86-6 structure

28523-86-6 structure

Name: sevoflurane
Chemical Name: sevoflurane
CAS Number: 28523-86-6
Molecular Formula: C₄H₃F₇O
Molecular Weight: 200.055
Catalog: API Anesthetic Agents General anesthetics
Create Date: 2018-02-05 08:00:00
Modify Date: 2026-07-01 19:27:03

Name	sevoflurane
Synonyms	1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propan Sevoness Sevofurane Propane,1,1,1,3,3,3-hexafluoro-2-(fluoroMethoxy) R-E 347 2-(Fluoromethoxy)-1,1,1,3,3,3-hexafluoropropane, 1,1,1,4-Tetrafluoro-2-(trifluoromethyl)-3-oxabutane, Sevoflurane Qi Fu Wan fluoromethyl2,2,2-trifluoro-1-(trifluoromethyl)ethyl-ethe fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether R-E Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl (8CI) fluoromethyl2,2,2-trifluoro-1-(trifluoromethyl)ethylether 1,1,1,3,3,3-HEXAFLUOROISOPROPYL FLUOROMETHYL ETHER 1,1,1,3,3,3-Hexafluoroisopropyl Ether Sevorane 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane Fluoromethyl 1-(trifluoromethyl)-2,2,2-trifluoroethyl ether MFCD00153189 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane, Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether, Sevoflurane Sevoflurane //BP Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether Sevofrane Propane, 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (9CI) mr6s4 Sevoflurane, 10 mM in DMSO Fluoromethyl 1,1,1,3,3,3-hexafluoropropan-2-yl ether 347mmzEbg 1,1,1,3,3,3-HEXAFLUORO-2-(FLUOROMETHOXY)PROPANE 1H,1H,3H-Perfluoro(3-methyl-2-oxabutane) Fluoromethyl 2H-hexafluoroprop-2-yl ether Sevoflurane RS SEVOFLURANE Ultane oxyde de fluorométhyle et de 2,2,2-trifluoro-1-(trifluorométhyl)éthyle Sevoflurane Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (Sevoflurane) Fluoromethy 2，2，2-trifluoro-1-(trifluoromethyl)ethyl ether Fluormethyl-2,2,2-trifluor-1-(trifluormethyl)ethylether Seven halothane Fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether

Density	1.4±0.1 g/cm3
Boiling Point	49.5±35.0 °C at 760 mmHg
Melting Point	50-60ºC
Molecular Formula	C₄H₃F₇O
Molecular Weight	200.055
Flash Point	-11.4±21.8 °C
Exact Mass	200.007217
PSA	9.23000
LogP	2.48
Vapour Pressure	311.5±0.1 mmHg at 25°C
Index of Refraction	1.266

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KO0737000

CHEMICAL NAME :: Ether, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-

CAS REGISTRY NUMBER :: 28523-86-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H3-F7-O

MOLECULAR WEIGHT :: 200.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28800 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28300 ppm/3H

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5497,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,591,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 6600 ppm/3H

SEX/DURATION :: male 64 day(s) pre-mating female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 2 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 pph/3H

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,5505,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	UN 3334
RTECS	KO0737000

Precursor 9
26103-07-1 373-53-5 920-66-1 373-52-4
593-70-4 406-58-6 50-00-0 1152045-94-7
97614-43-2
DownStream 3
26103-07-1 13171-18-1 58109-34-5

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