19622-55-0

19622-55-0 structure

Name: Megazol
Chemical Name: 5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazol-2-amine
CAS Number: 19622-55-0
Molecular Formula: C₆H₆N₆O₂S
Molecular Weight: 226.21600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-02-10 20:18:55
Modify Date: 2024-01-10 02:16:53
Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections[1].

Name	5-(1-methyl-5-nitroimidazol-2-yl)-1,3,4-thiadiazol-2-amine
Synonyms	megazol Nitroimidazole thiadiazole

Description	Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	EC50: 0.01 μg/mL (T. b. brueei)[1]
In Vitro	Megazol has effective inhibitory against T. b. brueei AnTat 1-9 with an EC50 of 0.01 μg/mL[1].
In Vivo	Megazol (i.p. or p.o.; 20, 80 mg/kg) shows cure the acute disease in T. b. brueei infected Swiss mice[1]. Megazol alone not causes cure of mice carrying a subacute infection with involvement of the central nervous system (CNS) [1]. Megazol have remission effect combined suramin, without further relapse from the CNS[1]. Animal Model: Swiss mice[1] Dosage: 20, 80 mg/kg Administration: i.p., p.o. Result: Cured infection at 20 mg/kg (i.p) and at 80 mg/kg (p.o).

CHEMICAL NAME :: 1,3,4-Thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979