Name | 2-(4-hydroxyphenyl)-1-benzothiophen-6-ol |
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Synonyms |
2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thiophene
2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol 6-hydroxy-2-(4-hydroxyphenyl)benzo<b>thiophene ZTW RALOXIFENE CORE benzthiophene compound,3 |
Description | Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2]. |
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Related Catalog | |
In Vitro | Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2]. Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2]. Cell Proliferation Assay[2] Cell Line: T47D:A18/PKCα and T47D:A18-TAM1 cells Concentration: 100 nM Incubation Time: 10 days Result: Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Cell Viability Assay[2] Cell Line: MCF-7:5C cells Concentration: 100 nM Incubation Time: 9 days Result: Significantly inhibited the growth of MCF-7:5C cells. |
In Vivo | Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2]. Animal Model: 4-6 week old athymic mice (Harlan-Sprague-Dawley)[2] Dosage: 1.5 mg/animal Administration: p.o. ; daily for 2 weeks Result: Significantly reduced tumor volume. |
References |
Density | 1.383 |
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Boiling Point | 477ºC at 760 mmHg |
Melting Point | 295 °C(dec.) |
Molecular Formula | C14H10O2S |
Molecular Weight | 242.29300 |
Flash Point | 242.3ºC |
Exact Mass | 242.04000 |
PSA | 68.70000 |
LogP | 3.97950 |
Index of Refraction | 1.742 |
~71% 63676-22-2 |
Literature: Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066 |
~% 63676-22-2 |
Literature: Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401 |
~% 63676-22-2 |
Literature: Journal of Medicinal Chemistry, , vol. 27, # 8 p. 1057 - 1066 |
~% 63676-22-2 |
Literature: Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401 |
~% 63676-22-2 |
Literature: Journal of Medicinal Chemistry, , vol. 45, # 7 p. 1399 - 1401 |
~% 63676-22-2 |
Literature: Journal of Medicinal Chemistry, , vol. 27, # 8 p. 1057 - 1066 |
Precursor 6 | |
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DownStream 5 | |