Estrogen receptor modulator 1

Modify Date: 2025-08-25 19:01:13

Estrogen receptor modulator 1 Structure
Estrogen receptor modulator 1 structure
 Common Name Estrogen receptor modulator 1
CAS Number 63676-22-2 Molecular Weight 242.29300
Density 1.383 Boiling Point 477ºC at 760 mmHg
Molecular Formula C14H10O2S Melting Point 295 °C(dec.)
MSDS N/A Flash Point 242.3ºC

 Use of Estrogen receptor modulator 1


Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].

 Names

Name 2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
Synonym More Synonyms

 Estrogen receptor modulator 1 Biological Activity

Description Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].
Related Catalog
In Vitro Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2]. Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2]. Cell Proliferation Assay[2] Cell Line: T47D:A18/PKCα and T47D:A18-TAM1 cells Concentration: 100 nM Incubation Time: 10 days Result: Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. Cell Viability Assay[2] Cell Line: MCF-7:5C cells Concentration: 100 nM Incubation Time: 9 days Result: Significantly inhibited the growth of MCF-7:5C cells.
In Vivo Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2]. Animal Model: 4-6 week old athymic mice (Harlan-Sprague-Dawley)[2] Dosage: 1.5 mg/animal Administration: p.o. ; daily for 2 weeks Result: Significantly reduced tumor volume.
References

[1]. Brogi S, et al. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013 Sep;67:344-51.

[2]. Molloy ME, et al. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2014 Nov;13(11):2515-26.

 Chemical & Physical Properties

Density 1.383
Boiling Point 477ºC at 760 mmHg
Melting Point 295 °C(dec.)
Molecular Formula C14H10O2S
Molecular Weight 242.29300
Flash Point 242.3ºC
Exact Mass 242.04000
PSA 68.70000
LogP 3.97950
Index of Refraction 1.742

 Synonyms

2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thiophene
2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol
2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
6-hydroxy-2-(4-hydroxyphenyl)benzo<b>thiophene
ZTW
RALOXIFENE CORE
benzthiophene compound,3
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