Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (2Z)-(2H2)-2-Butenedioic acid
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

24461-33-4

24461-33-4 structure

24461-33-4 structure

Name: (2Z)-(2H2)-2-Butenedioic acid
Chemical Name: maleic-2,3-d2 acid
CAS Number: 24461-33-4
Molecular Formula: C₄H₂D₂O₄
Molecular Weight: 118.085
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-10-04 10:45:27
Modify Date: 2024-01-06 22:07:56
Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

Name	maleic-2,3-d2 acid
Synonyms	Butylxanthogenic acid thioanhydride bis-butoxythiocarbonyl-sulfane CARBONIC ACID,DITHIO-,ANHYDROSULFIDE,O,O-DIBUTYL ESTER O,O-di-butyltrithiodicarbonate 2-Butenedioic-2,3-d acid, (2Z)- Xanthic acid,butyl-,anhydrosulfide ester O,O'-Dideuterio-maleinsaeure Thioanhydrid der Butylxanthogensaeure Bis-butoxythiocarbonyl-sulfan O,O'-dideuterio-maleic acid (2Z)-(H)-2-Butenedioic acid (2Z)-(H)But-2-enedioic acid

Description	Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9. [3]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb69:96-104.

Density	1.5±0.1 g/cm3
Boiling Point	355.5±25.0 °C at 760 mmHg
Melting Point	137-140ºC(lit.)
Molecular Formula	C₄H₂D₂O₄
Molecular Weight	118.085
Flash Point	183.0±19.7 °C
Exact Mass	118.023514
PSA	74.60000
LogP	-0.01
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.526

Hazard Codes	Xn