547-75-1

547-75-1 structure

Name: Hyocholic Acid
Chemical Name: hyocholic acid
CAS Number: 547-75-1
Molecular Formula: C₂₄H₄₀O₅
Molecular Weight: 408.571
Catalog: Research Areas Metabolic Disease
Create Date: 2018-09-20 12:22:45
Modify Date: 2024-01-05 17:27:14
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].

Name	hyocholic acid
Synonyms	3Alpha,6Alpha,7Alpha-Trihydroxy-5Beta-cholanic Acid Hyocholic Acid Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α)- (3α,5β,6α,7α)-3,6,7-Trihydroxycholan-24-oic acid 3a,6a,7a-Trihydroxy-5b-cholan-24-oic acid

Description	Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells[3]. HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells[3]. Western Blot Analysis[3] Cell Line: NCI-H716 cells Concentration: 50 μM Incubation Time: 48 h Result: Inhibited the high expression of SHP (small heterodimer partner) induced by the FXR agonist.
In Vivo	Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3]. Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3]. Animal Model: BA depletion pigs[3] Dosage: 20 mg/kg Administration: Oral administration (p.o.) Result: Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. Animal Model: db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] Dosage: 100 mg/kg/day Administration: Oral administration (p.o.) Result: Improved oral glucose tolerances shown by lower glucose levels. Increased circulating active GLP-1 levels and fasting insulin levels.
References	[1]. Zheng X, et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nat Commun. 2021 Mar 5;12(1):1487. [2]. van Berge Henegouwen, et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17(11), 861-869 (1976). [3]. Xiaojiao Zheng, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7.

Density	1.2±0.1 g/cm3
Boiling Point	565.7±40.0 °C at 760 mmHg
Melting Point	188-189ºC
Molecular Formula	C₂₄H₄₀O₅
Molecular Weight	408.571
Flash Point	310.0±23.8 °C
Exact Mass	408.287567
PSA	97.99000
LogP	3.82
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.558

Precursor 7
10538-59-7 10452-65-0 3057-04-3 108760-45-8
88725-42-2 4651-67-6 10452-64-9
DownStream 4
3057-04-3 2868-48-6 10190-22-4 2862-62-6

547-75-1	21066-18-2
64898-86-8	2432-85-1
2432-81-7	2432-46-4
11043-91-7	243869-48-9
105603-54-1	14047-56-4
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
2034605-16-6	6906-52-1
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1