Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cholan-24-oic acid,3,6,7-trihydroxy-, (3alpha,5beta,6alpha,7alpha)-
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547-75-1

547-75-1 structure

Name: Hyocholic Acid
Chemical Name: hyocholic acid
CAS Number: 547-75-1
Molecular Formula: C₂₄H₄₀O₅
Molecular Weight: 408.571
Catalog: Research Areas Metabolic Disease
Create Date: 2018-09-20 12:22:45
Modify Date: 2026-07-01 16:03:55
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].

Name	hyocholic acid
Synonyms	3-ALPHA,6-ALPHA,7-ALPHA-TRIHYDROXY-5-BETA-CHOLAN-24-OIC ACID Hyocholic acid Impurity 1 (R)-4-((3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid 3A,6A-7A-TRIHYDROXY-5B-CHOLAN-24-OIC ACID alpha-Hyocholic acid 5B-CHOLAN-24-OIC ACID-3A,6A,7A-TRIOL (4R)-4-[(3R,5R,6R,7S,8S,9S,10R,13R,14S,17R)-3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid Porcine cholic acid 2H5]-γ-Muricholic Acid trihydroxy-5B2 5β-Cholan-24-Oic Acid-3α,6α,7α-Triol 5-BETA-CHOLANIC ACID-3-ALPHA, 6-ALPHA, 7-ALPHA-TRIOL 3Alpha,6Alpha,7Alpha-Trihydroxy-5Beta-cholanic Acid 3α,6α,7α-Trihydroxy-5β-cholan-24-oic acid γ-Muricholic Acid/Hyocholic Acid HYOCHOLIC ACIDHYOCHOLIC ACID cholan-24-oic acid gamma-Muricholate 3a,6a,7a-Trihydroxy-5b-cholan-24-oic acid 5β-Cholanic acid-3α,6α,7α-triol 5-BETA-CHOLAN-24-OIC ACID-3-ALPHA,6-ALPHA,7-ALPHA-TRIOL 6B1 trihydroxy-5u0003B2 (3α,5β,6α,7α)-3,6,7-Trihydroxycholan-24-oic acid 3-ALPHA,6-ALPHA,7-ALPHA 3a,6a,7a-Trihydroxy-5b-cholanic acid 3u0003B1 6u0003B1 7u0003B1 Allocholic Acid Impurity 11 (Hyocholic Acid) 4-(3,6,7-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid Cholan-24-oic acid, 3,6,7-trihydroxy-, (3α,5β,6α,7α) Hyocholic acid (HCA) Hyocholic acid, 10 mM in DMSO 3,6,7-trihydroxy-5-cholan-24-oic acid HYOCHOLIC ACID GAMMA MURICHOLIC 3α,6α,7α-Trihydroxy-5β-cholanic Acid LAMBDA-MURICHOLIC ACID 3,6,7-trihydroxy-,(3alpha,5beta,6alpha,7alpha)-cholan-24-oicaci D5-γ-Muricholic Acid GAMMA-MURICHOLIC ACID

Description	Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells[3]. HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells[3]. Western Blot Analysis[3] Cell Line: NCI-H716 cells Concentration: 50 μM Incubation Time: 48 h Result: Inhibited the high expression of SHP (small heterodimer partner) induced by the FXR agonist.
In Vivo	Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3]. Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3]. Animal Model: BA depletion pigs[3] Dosage: 20 mg/kg Administration: Oral administration (p.o.) Result: Attenuated the increased blood glucose levels corresponding with GLP-1 decrease. Animal Model: db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model[3] Dosage: 100 mg/kg/day Administration: Oral administration (p.o.) Result: Improved oral glucose tolerances shown by lower glucose levels. Increased circulating active GLP-1 levels and fasting insulin levels.
References	[1]. Zheng X, et al. Hyocholic acid species as novel biomarkers for metabolic disorders. Nat Commun. 2021 Mar 5;12(1):1487. [2]. van Berge Henegouwen, et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17(11), 861-869 (1976). [3]. Xiaojiao Zheng, et al. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metab. 2021 Apr 6;33(4):791-803.e7.

Density	1.2±0.1 g/cm3
Boiling Point	565.7±40.0 °C at 760 mmHg
Melting Point	188-189ºC
Molecular Formula	C₂₄H₄₀O₅
Molecular Weight	408.571
Flash Point	310.0±23.8 °C
Exact Mass	408.287567
PSA	97.99000
LogP	3.82
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.558

Precursor 7
10538-59-7 10452-65-0 3057-04-3 108760-45-8
88725-42-2 4651-67-6 10452-64-9
DownStream 4
3057-04-3 2868-48-6 10190-22-4 2862-62-6

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