931399-19-8

931399-19-8 structure

Name: GSK360A
Chemical Name: 2-[[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid
CAS Number: 931399-19-8
Molecular Formula: C₁₇H₁₇FN₂O₅
Molecular Weight: 348.33
Create Date: 2017-03-20 05:10:52
Modify Date: 2024-01-02 18:37:28
GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) [1].

Name	2-[[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid
Synonyms	gsk360a

Description	GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. GSK360A activates the HIF-1 alpha pathway and protect the failing heart after myocardial infarction (MI) [1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
In Vivo	GSK360A (30 mg/kg i.g.) 在已建立的心室功能障碍模型中改善长期心室功能、重塑和血管分布[1]。 Animal Model: male Lewis rats with ventricular dysfunction model[1] Dosage: 30 mg/kg Administration: oral gavage Result: Increased circulating levels of erythropoietin and hemoglobin and hemoxygenase-1 expression in the heart and skeletal muscle of male rats.
References	[1]. Bao W, et, al. Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat. J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55.