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5650-20-4

5650-20-4 structure
5650-20-4 structure
  • Name: Ethyl-PEG4-alcohol
  • Chemical Name: 2-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]ethanol
  • CAS Number: 5650-20-4
  • Molecular Formula: C10H22O5
  • Molecular Weight: 222.27900
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-25 09:32:42
  • Modify Date: 2025-08-25 15:30:22
  • Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name 2-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]ethanol
Synonyms 3,6,9,12-Tetraoxatetradecanol
3,6,9,12-Tetraoxa-1-tetradecanol
EINECS 227-090-6
2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethanol
tetra(ethylene glycol) monoethyl ether
3,6,9,12-Tetraoxatetradecan-1-ol
Description Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Density 1.026g/cm3
Boiling Point 302.2ºC at 760mmHg
Molecular Formula C10H22O5
Molecular Weight 222.27900
Flash Point 136.6ºC
Exact Mass 222.14700
PSA 57.15000
LogP 0.06500
Index of Refraction 1.438
112-60-7 structure

112-60-7

75-03-6 structure

75-03-6

~65%

5650-20-4 structure

5650-20-4

Literature: Philippen, Annie; Degueil-Castaing, Marie; Beckwith, Athelstan L. J.; Maillard, Bernard Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6814 - 6819
74-96-4 structure

74-96-4

112-60-7 structure

112-60-7

~26%

5650-20-4 structure

5650-20-4

Literature: Cao, Yang; Zhang, Minjia; Wu, Cindy; Lee, Selina; Wroblewski, Mary Elizabeth; Whipple, Trisha; Nagy, Peter I.; Takacs-Novak, Krisztina; Balazs, Attila; Toroes, Szilard; Messer Jr., William S. Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4273 - 4286
54176-27-1 structure

54176-27-1

111-46-6 structure

111-46-6

~22%

5650-20-4 structure

5650-20-4

Literature: Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007
111-90-0 structure

111-90-0

~%

5650-20-4 structure

5650-20-4

Literature: Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007
75-21-8 structure

75-21-8

64-17-5 structure

64-17-5

~%

5650-20-4 structure

5650-20-4

Literature: I.G.Farbenind. Patent: DE542765 , 1925 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 174
75-21-8 structure

75-21-8

111-90-0 structure

111-90-0

~%

112-50-5 structure

112-50-5

5650-20-4 structure

5650-20-4

Literature: Union Carbide and Carbon Corp. Patent: US2053708 , 1934 ;
60558-75-0 structure

60558-75-0

~%

5650-20-4 structure

5650-20-4

Literature: Hiratani,K. et al. Israel Journal of Chemistry, 1979 , vol. 18, p. 208 - 213
41771-35-1 structure

41771-35-1

111-46-6 structure

111-46-6

~%

5650-20-4 structure

5650-20-4

Literature: Heimann, Ulrich; Voegtle, Fritz Liebigs Annalen der Chemie, 1980 , # 6 p. 858 - 862
75-21-8 structure

75-21-8

111-90-0 structure

111-90-0

141-43-5 structure

141-43-5

~%

112-50-5 structure

112-50-5

Detail
Literature: Union Carbide and Carbon Corp. Patent: US2053708 , 1934 ;
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