Ethyl-PEG4-alcohol

Modify Date: 2024-01-05 21:28:05

Ethyl-PEG4-alcohol Structure
Ethyl-PEG4-alcohol structure
Common Name Ethyl-PEG4-alcohol
CAS Number 5650-20-4 Molecular Weight 222.27900
Density 1.026g/cm3 Boiling Point 302.2ºC at 760mmHg
Molecular Formula C10H22O5 Melting Point N/A
MSDS N/A Flash Point 136.6ºC

 Use of Ethyl-PEG4-alcohol


Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Ethyl-PEG4-alcohol Biological Activity

Description Ethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.026g/cm3
Boiling Point 302.2ºC at 760mmHg
Molecular Formula C10H22O5
Molecular Weight 222.27900
Flash Point 136.6ºC
Exact Mass 222.14700
PSA 57.15000
LogP 0.06500
Index of Refraction 1.438

 Synthetic Route

~65%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Philippen, Annie; Degueil-Castaing, Marie; Beckwith, Athelstan L. J.; Maillard, Bernard Journal of Organic Chemistry, 1998 , vol. 63, # 20 p. 6814 - 6819

~26%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Cao, Yang; Zhang, Minjia; Wu, Cindy; Lee, Selina; Wroblewski, Mary Elizabeth; Whipple, Trisha; Nagy, Peter I.; Takacs-Novak, Krisztina; Balazs, Attila; Toroes, Szilard; Messer Jr., William S. Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4273 - 4286

~22%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007

~%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Dong, Chang-Zhi; Ahamada-Himidi, Azali; Plocki, Stephanie; Aoun, Darina; Touaibia, Mohamed; Meddad-Bel Habich, Nadia; Huet, Jack; Redeuilh, Catherine; Ombetta, Jean-Edouard; Godfroid, Jean-Jacques; Massicot, France; Heymans, Francoise Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 1989 - 2007

~%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: I.G.Farbenind. Patent: DE542765 , 1925 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 174

~%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Union Carbide and Carbon Corp. Patent: US2053708 , 1934 ;

~%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Hiratani,K. et al. Israel Journal of Chemistry, 1979 , vol. 18, p. 208 - 213

~%

Ethyl-PEG4-alcohol Structure

Ethyl-PEG4-alcohol

CAS#:5650-20-4

Literature: Heimann, Ulrich; Voegtle, Fritz Liebigs Annalen der Chemie, 1980 , # 6 p. 858 - 862

~%

Detail
Literature: Union Carbide and Carbon Corp. Patent: US2053708 , 1934 ;

 Synonyms

3,6,9,12-Tetraoxatetradecanol
3,6,9,12-Tetraoxa-1-tetradecanol
EINECS 227-090-6
2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethanol
tetra(ethylene glycol) monoethyl ether
3,6,9,12-Tetraoxatetradecan-1-ol