75288-96-9

75288-96-9 structure

Name: Kukoamine A
Chemical Name: N1,N12-bis(dihydrocaffeoyl)spermine
CAS Number: 75288-96-9
Molecular Formula: C₂₈H₄₂N₄O₆
Molecular Weight: 530.656
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-09-14 13:52:04
Modify Date: 2025-08-25 16:56:11
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

Name	N1,N12-bis(dihydrocaffeoyl)spermine
Synonyms	.N1,N14-bis(dihydrocaffeoyl)spermine Kukoamine A N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] bis-dihydrocaffeoylspermine N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] Benzenepropanamide, N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy- .kukoamine A

Description	Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	Ki: 1.8 μM (Trypanothione reductase)[1]
References	[1]. Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.