Kukoamine A structure
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Common Name | Kukoamine A | ||
|---|---|---|---|---|
| CAS Number | 75288-96-9 | Molecular Weight | 530.656 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 872.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C28H42N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 481.2±34.3 °C | |
Use of Kukoamine AKukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1]. |
| Name | N1,N12-bis(dihydrocaffeoyl)spermine |
|---|---|
| Synonym | More Synonyms |
| Description | Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 1.8 μM (Trypanothione reductase)[1] |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 872.1±65.0 °C at 760 mmHg |
| Molecular Formula | C28H42N4O6 |
| Molecular Weight | 530.656 |
| Flash Point | 481.2±34.3 °C |
| Exact Mass | 530.310425 |
| PSA | 163.18000 |
| LogP | -0.17 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.588 |
| InChIKey | IOLDDENZPBFBHV-UHFFFAOYSA-N |
| SMILES | O=C(CCc1ccc(O)c(O)c1)NCCCNCCCCNCCCNC(=O)CCc1ccc(O)c(O)c1 |
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Name: Antioxidant activity against AAPH-induced lipid peroxidation assessed as inhibition o...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1638703
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|
Name: Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1638818
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|
Name: Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1638819
|
|
Name: Cytotoxicity against RAMEC assessed as cell viability after 24 hrs by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1638820
|
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Name: Natural log of the value in (uM) of inhibition constant was tested against Trypanothi...
Source: ChEMBL
Target: Trypanothione reductase
External Id: CHEMBL817698
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|
Name: Antiinflammatory activity in Fisher rat assessed as inhibition of carrageenan-induced...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1638821
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| .N1,N14-bis(dihydrocaffeoyl)spermine |
| Kukoamine A |
| N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] |
| bis-dihydrocaffeoylspermine |
| N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] |
| .kukoamine A |