106492-60-8

106492-60-8 structure

Name: Aminooxy-PEG4-alcohol
Chemical Name: 2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethanol
CAS Number: 106492-60-8
Molecular Formula: C₈H₁₉NO₅
Molecular Weight: 209.24000
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-05-02 18:14:39
Modify Date: 2024-01-16 09:14:03
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethanol

Description	Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1. [2]. Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3.