106518-63-2

106518-63-2 structure

Name: Ganodermanontriol
Chemical Name: (5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R,5S)-5,6,7-trihydroxy-6-methylheptan-2-yl]-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
CAS Number: 106518-63-2
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.700
Catalog: Natural product Moss
Create Date: 2018-05-10 08:00:00
Modify Date: 2024-01-02 11:56:31
Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity[1][2].

Name	(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R,5S)-5,6,7-trihydroxy-6-methylheptan-2-yl]-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonyms	Ganodermanontriol Lanosta-7,9(11)-dien-3-one, 24,25,26-trihydroxy-, (24S,25R)- (24S,25R)-24,25,26-Trihydroxylanosta-7,9(11)-dien-3-one

Description	Ganodermanontriol, a sterol isolated from Ganoderma lucidum, induces anti-inflammatory activity in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the expression of HO-1. Ganodermanontriol exhibits hepatoprotective activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Ganodermanontriol inhibits breast cancer cell lines MCF-7 and MDA-MB-231with IC50 values of 5.8 and 9.7 μM, respectively[2].
References	[1]. Ha do T, et al. In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress. Ethnopharmacol. 2013 Dec 12;150(3):875-85. [2]. Kennedy EM, et al. Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat Prod. 2011 Nov 28;74(11):2332-7.