124961-67-7

124961-67-7 structure

Name: Ajugamarin L2
Chemical Name: [(4aR,5S,7R,8S,8aR)-5-hydroxy-7,8-dimethyl-8-[2-(5-oxo-2H-furan-3-yl)ethyl]spiro[2,3,5,6,7,8a-hexahydro-1H-naphthalene-4,2'-oxirane]-4a-yl]methyl (E)-2-methylbut-2-enoate
CAS Number: 124961-67-7
Molecular Formula: C₂₅H₃₆O₆
Molecular Weight: 432.55000
Catalog: Research Areas Others
Create Date: 2016-11-19 19:02:34
Modify Date: 2024-01-20 15:31:06
Ajudecunoid A is nature product that could be isolated from Ajuga decumbens. Ajudecunoid A inhibits RANKL-Induced osteoclastogenesis[1].

Name	[(4aR,5S,7R,8S,8aR)-5-hydroxy-7,8-dimethyl-8-[2-(5-oxo-2H-furan-3-yl)ethyl]spiro[2,3,5,6,7,8a-hexahydro-1H-naphthalene-4,2'-oxirane]-4a-yl]methyl (E)-2-methylbut-2-enoate
Synonyms	Ajugacumbin B Ajugamarin L2

Description	Ajudecunoid A is nature product that could be isolated from Ajuga decumbens. Ajudecunoid A inhibits RANKL-Induced osteoclastogenesis[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Ajudecunoid A (compound 1; 3 and 10 μM; 48 h) 以浓度依赖性方式抑制 RANKL 诱导的破骨细胞生成[1]。 Cell Viability Assay[1] Cell Line: Osteoclastogenesis Concentration: 3 and 10 Μm Incubation Time: 48 hours Result: Inhibited RANKL-induced osteoclastogenesis in a concentration dependent manner.
References	[1]. Wang H, et, al. Diterpenoids from the Whole Plants of Ajuga nipponensis and Their Inhibition of RANKL-Induced Osteoclastogenesis. Chem Biodivers. 2021 Jan;18(1):e2000780.