37717-21-8

37717-21-8 structure

Name: Flurocitabine
Chemical Name: Flurocitabine
CAS Number: 37717-21-8
Molecular Formula: C₉H₁₀FN₃O₄
Molecular Weight: 243.19200
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-05-08 08:00:00
Modify Date: 2024-01-11 19:14:08
Flurocitabine is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine has antitumor activity during phase I studies in acute leukemia and solid tumors[1].

Name	Flurocitabine
Synonyms	5-fluoro-arabino-O2,O2'-cyclocytidine Ro-21-0702 fluoroancitabine 5-Fluoro-2,2'-cyclocytidine 5-fluoro-arabino-2,2'-anhydro-cytidine Fluorocitabin 5-Fluor-2,2'-cyclocytidin AAFC

Description	Flurocitabine is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine has antitumor activity during phase I studies in acute leukemia and solid tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14(2):195-201.

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - normocytic anemia Blood - leukopenia

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,2657,1974