37717-21-8

• 常用中文名：氟西他宾
• 常用英文名：Flurocitabine
• CAS号：37717-21-8
• 分子式：C₉H₁₀FN₃O₄
• 分子量：243.19200
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-05-08 08:00:00
• 更新时间：2026-08-06 21:30:36
• 氟罗西他滨是阿糖胞苷的一种含氟酰肼类似物,在体内部分水解成两种活性抗肿瘤物质(阿糖基三氟胞苷(ara-FC)和阿糖基氟尿嘧啶(ara-FU))。氟罗西他滨在急性白血病和实体瘤的I期研究中具有抗肿瘤活性[1]。

名称

• 中文名: 氟西他宾
• 英文名: Flurocitabine
• 中文别名: 5-氟-2,2'-环胞苷; 氟西他滨
• 英文别名: Fluorocitabin; AAFC; (2R)-7-Fluoro-2,3,3aβ,9aβ-tetrahydro-3β-hydroxy-6-imino-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2α-methanol; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol, 7-fluoro-2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-, (2R,3R,3aS,9); NSC-166641; 5-fluoro-arabino-O2,O2'-cyclocytidine; 5-Fluor-2,2'-cyclocytidin; (2R,3R,3aS,9-7-Fluoro-2,3,3a,9a-tetrahydro-3-hydroxy-6-iMino-6H-furo(2',3':4,5)oxazolo(3,2-a)pyriMidine-2-Methanol; Ro-21-0702; fluoroancitabine; 5-fluoro-arabino-2,2'-anhydro-cytidine; 5-Fluoro-2,2'-cyclocytidine

物化性质

• 密度: 2.11g/cm3
• 沸点: 391.7ºC at 760mmHg
• 分子式: C₉H₁₀FN₃O₄
• 分子量: 243.19200
• 闪点: 190.7ºC
• 精确质量: 243.06600
• PSA: 100.59000
• 折射率: 1.813

生物活性

• 描述: 氟罗西他滨是阿糖胞苷的一种含氟酰肼类似物,在体内部分水解成两种活性抗肿瘤物质(阿糖基三氟胞苷(ara-FC)和阿糖基氟尿嘧啶(ara-FU))。氟罗西他滨在急性白血病和实体瘤的I期研究中具有抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Alberto P, et al. Phase II study of anhydro-ara-5-fluorocytidine in adenocarcinoma of gastrointestinal tract, epidermoid carcinoma of lung, head and neck, breast carcinoma and small cell anaplastic carcinoma of lung. A study report of the E.O.R.T.C. early clinical trial cooperative group. Eur J Cancer. 1978;14(2):195-201.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HA5400000 CHEMICAL NAME : Cytosine, 2,2'-anhydroarabino-5-fluoro- CAS REGISTRY NUMBER : 37717-21-8 LAST UPDATED : 199706 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H10-F-N3-O4 MOLECULAR WEIGHT : 243.22 WISWESSER LINE NOTATION : T B556 AN CO GO IN HHTT&J D1Q EQ JZ KF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Blood - normocytic anemia Blood - leukopenia MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 1 mmol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,2657,1974