740-33-0

740-33-0 structure

Name: Mosloflavone
Chemical Name: 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
CAS Number: 740-33-0
Molecular Formula: C₁₇H₁₄O₅
Molecular Weight: 298.290
Catalog: Biochemical Plant extracts
Create Date: 2018-03-19 08:00:00
Modify Date: 2024-01-02 20:31:48
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.

Name	5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one
Synonyms	5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one 5-Hydroxy-6,7-dimethoxy-2-phenyl-4H-chromen-4-one baicalein 6,7-dimethyl ether 4H-1-Benzopyran-4-one, 5-hydroxy-6,7-dimethoxy-2-phenyl- Mosloflavone 5-hydroxy-6,7-dimethoxyflavone

Description	Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with anti-EV71 activity. Mosloflavone inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: EV71; bacterial[1][2]
In Vitro	Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; inhibits TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A as a dose-dependent manner, it also can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases[2].
References	[1]. 2.Choi HJ, et al. Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8. [2]. 2.Hnamte S, et al. Mosloflavone attenuates the quorum sensing controlled virulence phenotypes and biofilm formation in Pseudomonas aeruginosa PAO1: In vitro, in vivo and in silico approach.Microb Pathog. 2019 Jun;131:128-134. [3]. 4.Singh B, et al. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.Nat Prod Res. 2013;27(23):2227-30.

HS Code	2914509090

491-67-8

18107-18-1

~12%

740-33-0

Literature: YALE UNIVERSITY Patent: WO2005/75449 A1, 2005 ; Location in patent: Page/Page column 30 ; WO 2005/075449 A1

973-67-1

~10%

740-33-0

1215208-44-8

124-41-4

~92%

740-33-0

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HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%