- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: oroxylin A
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: oroxylin A
- Price: ￥Inquiry/5mg
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: oroxylin A
- Price: ￥978.0/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Oroxylin A
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: Oroxylin A
- Price: $550.0/100mg $950.0/250mg $1900.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
480-11-5
480-11-5 structure
- Name: oroxylin A
- Chemical Name: oroxylin A
- CAS Number: 480-11-5
- Molecular Formula: C16H12O5
- Molecular Weight: 284.263
- Catalog: Natural product Flavonoids
- Create Date: 2018-07-04 22:50:41
- Modify Date: 2024-01-02 12:46:03
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Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].
| Name | oroxylin A |
|---|---|
| Synonyms |
Oroxylin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl- baicalein 6-methyl ether 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one 5,7-Dihydroxy-6-methoxyflavone 6-Methoxybaicalein oroxyllin-A 6-methoxy-5,7-dihydroxyflavone 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one oroxylin A 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Dihydroxy-6-methoxyflavone 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 4H-1-Benzopyran-4-one,5,7-dihydroxy-6-methoxy-2-phenyl |
| Description | Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 540.9±50.0 °C at 760 mmHg |
| Melting Point | 195-197ºC |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 207.4±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 79.90000 |
| LogP | 2.37 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Storage condition | 2-8°C |
| Precursor 10 | |
|---|---|
| DownStream 3 | |
