915303-09-2

915303-09-2 structure

Name: Indotecan(LMP400)
Chemical Name: indotecan
CAS Number: 915303-09-2
Molecular Formula: C₂₆H₂₆N₂O₇
Molecular Weight: 478.49400
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2016-01-17 06:06:05
Modify Date: 2024-01-13 18:36:34
Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

Name	indotecan
Synonyms	3-[(Morpholine)-1-propyl]-5,3-dimethoxy-8,9-meth ylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline UNII-BTA69L5M8D

Description	Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Cancer
Target	IC50：300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].
References	[1]. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.