34321-81-8

34321-81-8 structure

Name: Mal-PEG2-alcohol
Chemical Name: 1-[2-(2-hydroxyethoxy)ethyl]pyrrole-2,5-dione
CAS Number: 34321-81-8
Molecular Formula: C₈H₁₁NO₄
Molecular Weight: 185.17700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-09-08 02:51:26
Modify Date: 2024-01-09 21:47:55
Mal-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-[2-(2-hydroxyethoxy)ethyl]pyrrole-2,5-dione
Synonyms	MFCD16780862

Description	Mal-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₈H₁₁NO₄
Molecular Weight	185.17700
Exact Mass	185.06900
PSA	66.84000

55750-48-6

929-06-6

~92%

34321-81-8

Literature: Heredia, Karina L.; Bontempo, Debora; Ly, Tiffany; Byers, Joshua T.; Halstenberg, Sven; Maynard, Heather D. Journal of the American Chemical Society, 2005 , vol. 127, # 48 p. 16955 - 16960

55750-49-7

929-06-6

34321-81-8

Literature: Raouane, Mouna; Desmaele, Didier; Gilbert-Sirieix, Marie; Gueutin, Claire; Zouhiri, Fatima; Bourgaux, Claudie; Lepeltier, Elise; Gref, Ruxandra; Ben Salah, Ridha; Clayman, Gary; Massaad-Massade, Liliane; Couvreur, Patrick Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4067 - 4076

Precursor 3
55750-48-6 929-06-6 55750-49-7
DownStream 0

34321-81-8	2055041-38-6
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1374666-32-6	1807512-47-5