Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Calindol hydrochloride
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Calindol hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
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DC Chemicals Limited
China
Product Name: Calindol hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

729610-18-8

729610-18-8 structure

729610-18-8 structure

Name: Calindol hydrochloride
Chemical Name: (1R)-N-(1H-indol-2-ylmethyl)-1-naphthalen-1-ylethanamine,hydrochloride
CAS Number: 729610-18-8
Molecular Formula: C₂₁H₂₁ClN₂
Molecular Weight: 336.85800
Catalog: Signaling Pathways GPCR/G Protein CaSR
Create Date: 2017-01-12 06:17:03
Modify Date: 2024-01-11 17:43:53
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].

Name	(1R)-N-(1H-indol-2-ylmethyl)-1-naphthalen-1-ylethanamine,hydrochloride
Synonyms	Calindol Hydrochloride

Description	Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> CaSR
In Vitro	在 2mM Ca2+ 存在的情况下，Calindol 刺激磷脂酰肌醇 (PI) 在表达大鼠或人 CaSR 的细胞中的 EC50 分别为 1.0 μM 或 0.31 μM[2]。在线肌造影研究中，Calindol (1-10 µM) 抑制 Methoxamine 和 KCl 诱导的预收缩张力，并抑制兔肠系膜动脉中的全细胞电压门控 Ca2+ 通道 (VGCC) 电流[3]。
References	[1]. Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24(4):554-69. [2]. Albane Kessler, et al. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9. [3]. Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.

Molecular Formula	C₂₁H₂₁ClN₂
Molecular Weight	336.85800
Exact Mass	336.13900
PSA	27.82000
LogP	6.36480

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

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