66246-88-6

66246-88-6 structure

Name: penconazole
Chemical Name: penconazole
CAS Number: 66246-88-6
Molecular Formula: C₁₃H₁₅Cl₂N₃
Molecular Weight: 284.184
Catalog: Chemical pesticide Fungicide Other fungicides
Create Date: 2018-08-20 16:37:50
Modify Date: 2024-01-03 11:22:54
Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].

Name	penconazole
Synonyms	topasmz (RS)-1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole EINECS 266-275-6 PENCONAZOL T5NN DNJ A1Y3&R BG DG 1-[2-(2,4-Dichlorophenyl)pentyl]-1H-1,2,4-triazole onmex MFCD00078737 1-[2-(2,4-Dichlorophenyl)-n-pentyl]-1H-1,2,4-triazole Topas 1-(2,4-Dichloro-β-propylphenethyl)-1H-1,2,4-triazole topaze 1H-1,2,4-Triazole, 1-[2-(2,4-dichlorophenyl)pentyl]- topazec penconazole topasc Pine gel rac-1-[(2R)-2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole

Description	Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
In Vivo	Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2]. Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation, in addition to the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats[2]. Animal Model: Twelve male Wistar rats[2] Dosage: 67 mg/kg Administration: I.p.; every 2 days during 9 days Result: A significant increase was obtained in the absolute and relative weights of the cerebrum and cerebellum, respectively.
References	[1]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8. [2]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 2017;36(8):854-866.

Density	1.3±0.1 g/cm3
Boiling Point	415.3±55.0 °C at 760 mmHg
Melting Point	57.6-60.3ºC
Molecular Formula	C₁₃H₁₅Cl₂N₃
Molecular Weight	284.184
Flash Point	204.9±31.5 °C
Exact Mass	283.064301
PSA	30.71000
LogP	3.66
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.602
Storage condition	0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4615000

CHEMICAL NAME :: 1H-1,2,4-Triazole, 1-(2-(2,4-dichlorophenyl)pentyl)-

CAS REGISTRY NUMBER :: 66246-88-6

BEILSTEIN REFERENCE NO. :: 0541488

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H15-Cl2-N3

MOLECULAR WEIGHT :: 284.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,554,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302-H361d-H410
Precautionary Statements	P201-P273-P301 + P312 + P330-P308 + P313-P391-P501
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	UN 3077 9 / PGIII
RTECS	XZ4615000
HS Code	2933990015

89586-77-6

66246-88-6

Literature: US4556717 A1, ;

Precursor 1
89586-77-6
DownStream 0

HS Code	2933990016
Summary	2933990016 1-(2-(2,4-dichlorophenyl)pentyl)-1h-1,2,4-triazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

66246-88-6	1628110-84-8
94241-95-9	117660-41-0